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potassium voltage-gated channel, shaker-related subfamily, member 5

Summary

Gene Symbol

Kcna5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16493

PubChem

16493

Alliance of Genome Resources

MGI:96662

Annotation

Keyword

Alternative splicing
Cell membrane
Glycoprotein
Isopeptide bond
Palmitate
Phosphoprotein
Potassium channel
Reference proteome
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61762	Voltage-gated potassium channel subunit Kv1.5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
regulation of heart rate by cardiac conduction	IEA ISO
potassium ion export across plasma membrane	IEA ISO
potassium ion transmembrane transport	IBA IEA ISO
regulation of membrane potential	IGI ISO	15277200
regulation of potassium ion transport	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

protein homooligomerization

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

potassium ion homeostasis

inorganic ion homeostasis [inference]

potassium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to hyperoxia

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to increased oxygen levels [inference]

response to hyperoxia

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

regulation of myoblast proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of vasoconstriction

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of atrial cardiac muscle cell membrane repolarization

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential

action potential

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

atrial cardiac muscle cell action potential

membrane hyperpolarization

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of atrial cardiac muscle cell membrane repolarization

membrane repolarization [inference]

membrane repolarization during action potential [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

cardiac muscle cell membrane repolarization [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

atrial cardiac muscle cell membrane repolarization [inference]

membrane repolarization during atrial cardiac muscle cell action potential

negative regulation of cytosolic calcium ion concentration

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA ISO ISS	15277200
Z disc	IEA ISO
intracellular canaliculus	IEA ISO
intercalated disc	IBA IDA ISO	18603586
voltage-gated potassium channel complex	IBA ISO ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
alpha-actinin binding	IEA ISO
protein kinase binding	IEA ISO
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	IEA ISO
voltage-gated potassium channel activity	IDA	11349004 8226976
protein binding	IPI	15277200 18603586 29306897

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

binding [inference]

protein binding

signaling receptor binding

cytoskeletal protein binding [inference]

actinin binding [inference]

alpha-actinin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

scaffold protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050650	familial atrial fibrillation	Alliance of Genome Resources
DOID:0050989	episodic ataxia type 1	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources

GlyTouCan

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UniCarb-DR

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External Links

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International Collaboration

Acknowledgements