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dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Summary

Gene Symbol

DDOST

Aliases

KIAA0115
OST
OST48
WBP1
advanced glycation end-product receptor 1
oligosaccharyltransferase subunit 48

Organism

Homo sapiens (human)

External Links

NCBI Gene

1650

HGNC

2728

KEGG Gene ID

hsa:1650

PubChem

1650

Alliance of Genome Resources

HGNC:2728

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P39656

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA	31831667 9642163
protein N-linked glycosylation via asparagine	IBA IMP	22467853
response to cytokine	IDA	9642163
T cell activation	IDA	9642163
protein glycosylation	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine

biological regulation [inference]

regulation of biological quality [inference]

regulation of protein stability

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA	9642163
endoplasmic reticulum	IDA
azurophil granule membrane
endoplasmic reticulum membrane	NAS	31831667
oligosaccharyltransferase complex	IBA IDA IPI ISS	22467853 31831667 9642163

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

azurophil granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

azurophil granule membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
enzyme activator activity	IMP	22467853
protein binding	IPI	21903422 29765154

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000244038

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12670

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase subunit DDOST/WBP1

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110741	type 1 diabetes mellitus 2	DisGeNET
DOID:0110742	type 1 diabetes mellitus 3	DisGeNET
DOID:0110743	type 1 diabetes mellitus 4	DisGeNET
DOID:0110744	type 1 diabetes mellitus 5	DisGeNET
DOID:0110745	type 1 diabetes mellitus 6	DisGeNET
DOID:0050570	congenital disorder of glycosylation type I	DisGeNET
DOID:0080569	congenital disorder of glycosylation Ir	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0090078	hypogonadotropic hypogonadism 7 with or without anosmia	DisGeNET
DOID:0110746	type 1 diabetes mellitus 7	DisGeNET
DOID:0110747	type 1 diabetes mellitus 8	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000486	Strabismus
HP:0000565	Esotropia
HP:0000832	Primary hypothyroidism
HP:0000938	Osteopenia
HP:0000958	Dry skin
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001290	Generalized hypotonia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:614507	DDOST-congenital disorder of glycosylation
ORPHA:300536	DDOST-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

Congenital disorder of glycosylation type Ir

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ir; CDG1R

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003541
Gene Name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	174268	WB:WBGene00011638
Drosophila melanogaster	31849	FB:FBgn0014868
Ciona intestinalis	100178567		CIOIN05985
Callorhinchus milii	103187645		CALMI37200
Danio rerio	406408	ZFIN:ZDB-GENE-040426-2147	DANRE24253
Astyanax mexicanus	103027807		ASTMX05228
Ictalurus punctatus	100304809		ICTPU07933
Electrophorus electricus	113580144		ELEEL25914
Salmo salar	106566864		SALSA65057
Salmo salar	106572011		SALSA78607

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GlyComb

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UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements