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potassium voltage-gated channel, subfamily Q, member 2

Summary

Gene Symbol

Kcnq2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16536

PubChem

16536

Alliance of Genome Resources

MGI:1309503

Annotation

Keyword

Alternative splicing
Cell membrane
Phosphoprotein
Potassium channel
Proteomics identification
Reference proteome
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

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UniProt	Protein Name
Q3UY10
B7ZBV5
A0A0G2JFQ2
Q9Z351	KQT-like 2 Potassium channel subunit alpha KvLQT2 Voltage-gated potassium channel subunit Kv7.2
B7ZBW2
B7ZBV7
B7ZBV6
B7ZBV8
B7ZBV9
B7ZBW1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
inhibitory chemical synaptic transmission	IGI	30382937
transmission of nerve impulse	IMP	10854243 23977150
sensory perception of sound	IGI	23716673
endocytosis	IMP	21466805
response to organic cyclic compound	IDA	20885443

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

vesicle-mediated transport [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

pyramidal neuron differentiation [inference]

hippocampal pyramidal neuron differentiation

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

apoptosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

apoptosome assembly

export from cell [inference]

secretion by cell [inference]

exocytosis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

transmission of nerve impulse

cognition

learning or memory [inference]

behavior

learning or memory [inference]

motor behavior

psychomotor behavior

determination of adult lifespan

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

anatomical structure development [inference]

animal organ development [inference]

brain development

substantia propria of cornea development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

pyramidal neuron differentiation [inference]

hippocampal pyramidal neuron differentiation

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to auditory stimulus

response to abiotic stimulus [inference]

response to temperature stimulus

response to mechanical stimulus

response to auditory stimulus

response to chemical [inference]

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to organic cyclic compound

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

vesicle-mediated transport [inference]

secretion [inference]

secretion by cell [inference]

exocytosis

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

organic substance transport [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

import into cell [inference]

endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of action potential [inference]

regulation of action potential firing threshold

regulation of biological quality [inference]

regulation of membrane potential

action potential

regulation of mitochondrial membrane potential [inference]

mitochondrial depolarization

membrane depolarization [inference]

mitochondrial depolarization

membrane hyperpolarization

regulation of action potential [inference]

regulation of action potential firing threshold

regulation of synaptic plasticity

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GO Term	Evidence Code	PMID
voltage-gated potassium channel complex	IBA IGI ISO ISS	12223552
plasma membrane	IDA ISO	16525039
axon initial segment	IDA ISO	14762142 16525039 24333508
cell surface	IDA	12223552
mitochondrion	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	PMID
protein binding	IPI	14762142 24333508 27979964
ankyrin binding	ISO
voltage-gated monoatomic ion channel activity	IGI	12223552
calmodulin binding	IMP IPI ISO	12223552 24333508
potassium channel activity	IGI IMP	14762142 23716673

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

ankyrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

potassium voltage-gated channel subfamily KQT member 2

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport
potassium channel activity
voltage-gated potassium channel activity

Displaying **all 5** entries
InterPro
Ankyrin-G binding site
Ion transport domain
Potassium channel, voltage dependent, KCNQ, C-terminal
Potassium channel, voltage dependent, KCNQ2
Potassium channel, voltage dependent, KCNQ

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080462	developmental and epileptic encephalopathy 7	Alliance of Genome Resources
DOID:0112202	developmental and epileptic encephalopathy	Alliance of Genome Resources
DOID:10273	heart conduction disease	Alliance of Genome Resources
DOID:14264	benign neonatal seizures	Alliance of Genome Resources
DOID:2843	long QT syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3785		HGNC:6296	HUMAN57888
Drosophila melanogaster	36071		FB:FBgn0033494
Rattus norvegicus	170848	10116_1:0017c1	RGD:621504
Pan troglodytes	739390			PANTR25343
Monodelphis domestica	100019940			MONDO09352
Danio rerio	100141342		ZFIN:ZDB-GENE-080220-37
Equus caballus	100146986			HORSE21073
Taeniopygia guttata	100224829			TAEGU12290
Callithrix jacchus	100406083			CALJA33072
Pongo abelii	100435248			PONAB20855

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements