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keratin 2

Summary

Gene Symbol

Krt2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16681

PubChem

16681

Alliance of Genome Resources

MGI:96699

Annotation

Keyword

Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Ichthyosis
Intermediate filament
Keratin
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3TTY5	Cytokeratin-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e Type-II keratin Kb2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of epidermis development	IMP	26603179
keratinocyte proliferation	IEA ISO
keratinocyte development	IMP	24751727
epidermis development	IMP	24751727
peptide cross-linking	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

cell activation [inference]

keratinocyte activation

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

keratinocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

cell activation [inference]

keratinocyte activation

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of epidermis development

regulation of developmental process [inference]

regulation of epidermis development [inference]

positive regulation of epidermis development

positive regulation of developmental process [inference]

positive regulation of epidermis development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cornified envelope	IEA ISO
keratin filament	IBA IDA	24751727
cytoplasm	IDA ISO ISS	24751727

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane [inference]

cornified envelope

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament [inference]

keratin filament

Displaying **all 2** entries
GO Term	Evidence Code	PMID
structural constituent of skin epidermis	IBA IMP ISO	24751727
cytoskeletal protein binding	IMP	24751727

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of skin epidermis

binding [inference]

protein binding [inference]

cytoskeletal protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Keratin, type II

Functional Category

P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
intermediate filament organization
keratinization
structural constituent of skin epidermis

Displaying **all 4** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain
Keratin type II head
Keratin, type II

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060877	bullous congenital ichthyosiform erythroderma	Alliance of Genome Resources
DOID:1697	ichthyosis	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 77 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Arvicola amphibius	119822776	1047088_0:003971
Microtus oregoni	121444225	111838_0:005f34
Dipodomys spectabilis	122098381	105255_0:004715
Panthera leo	122223578		PANLE16828
Ursus americanus	123794717		URSAM05825
Marmota monax	124087015	9995_0:004d1d
Sciurus carolinensis	124982491	30640_0:0016e9
Perognathus longimembris pacificus	125354683	214514_0:000535
Myodes glareolus	125410153	447135_0:002653
Microtus fortis	126493580	100897_0:004da5

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements