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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
defensin beta 1
Summary
- Gene Symbol
-
- DEFB1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Antibiotic
- Defensin
- Direct protein sequencing
- Disulfide bond
- Membrane
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P60022 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chemotaxis | ||
| response to bacterium | ||
| innate immune response in mucosa | ||
| antibacterial humoral response | ||
| calcium-mediated signaling |
GO Hierarchy
biological process
biological process involved in interspecies interaction between organisms [inference]
response to stimulus [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| sperm midpiece | ||
| membrane | ||
| Golgi lumen | ||
| microvesicle | ||
| extracellular region |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| identical protein binding | ||
| CCR6 chemokine receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- beta-defensin 1
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| CCR6 chemokine receptor binding |
| defense response to Gram-negative bacterium |
| defense response to Gram-positive bacterium |
| innate immune response in mucosa |
| InterPro |
|---|
| Beta defensin type |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12120 | pulmonary alveolar proteinosis | |
| DOID:13406 | pulmonary sarcoidosis | |
| DOID:2841 | asthma | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3770 | pulmonary fibrosis | |
| DOID:552 | pneumonia | |
| DOID:850 | lung disease | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9970 | obesity |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 13214 | MGI:1096878 | MOUSE58386 | ||
| 83687 | RGD:619943 | RATNO11388 | ||
| 353320 | MGI:2672966 | |||
| 404699 | PIGXX39588 | |||
| 450100 | 9598_0:0025fa | PANTR41936 | ||
| 574187 | MACMU43120 | |||
| 611241 | CANLF04831 | |||
| 652921 | RGD:1560790 | |||
| 100406393 | CALJA09136 | |||
| 100460518 | 9601_0:0023ad | PONAB34489 |
