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defensin beta 1

Summary

Gene Symbol

DEFB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1672

PubChem

1672

Alliance of Genome Resources

HGNC:2766

Annotation

Keyword

3D-structure
Antibiotic
Defensin
Direct protein sequencing
Disulfide bond
Membrane
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P60022	Defensin, beta 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
innate immune response in mucosa	IDA	12860195
innate immune response in mucosa	IBA
chemotaxis	TAS	10521347
immune response	TAS	10521347
G protein-coupled receptor signaling pathway	TAS	10521347

GO Hierarchy

biological process

immune system process [inference]

immune response

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

innate immune response

innate immune response in mucosa

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

reproductive process [inference]

positive regulation of flagellated sperm motility involved in capacitation

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium

innate immune response

innate immune response in mucosa

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium

innate immune response

innate immune response in mucosa

immune response

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

innate immune response

innate immune response in mucosa

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium

innate immune response

innate immune response in mucosa

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium

innate immune response

innate immune response in mucosa

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

regulation of cell motility [inference]

regulation of cilium-dependent cell motility [inference]

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cellular process [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of reproductive process [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of cilium movement [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cellular process [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

regulation of cell motility [inference]

regulation of cilium-dependent cell motility [inference]

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

regulation of reproductive process [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of reproductive process [inference]

positive regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility involved in capacitation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	12860195 21115716 7628632
extracellular space	IBA
Golgi lumen	TAS
membrane	IDA	23938203

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

sperm midpiece

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25122636 32296183
CCR6 chemokine receptor binding	IDA	25122636
CCR6 chemokine receptor binding	IBA
identical protein binding	IDA	23938203

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

CCR chemokine receptor binding [inference]

CCR6 chemokine receptor binding

cytokine receptor binding [inference]

chemokine receptor binding [inference]

CCR chemokine receptor binding [inference]

CCR6 chemokine receptor binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-defensin 1

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
CCR6 chemokine receptor binding
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
innate immune response in mucosa

Displaying 1 entry
InterPro
Beta defensin type

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:850	lung disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 31 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	1672	RGD:619943
Mus musculus	13214		MOUSE58386
Rattus norvegicus	83687		RATNO11388
Sus scrofa	404699		PIGXX39588
Pan troglodytes	450100		PANTR41936
Macaca mulatta	574187		MACMU43120
Canis lupus familiaris	611241		CANLF04831
Callithrix jacchus	100406393		CALJA09136
Pongo abelii	100460518		PONAB34489
Nomascus leucogenys	100592794		NOMLE28255