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LIF receptor alpha

Summary

Gene Symbol

Lifr

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16880

PubChem

16880

Alliance of Genome Resources

MGI:96788

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P42703	D-factor/LIF receptor
Q3UKU5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	ISO
positive regulation of cell population proliferation	IGI	15051883
positive regulation of cell population proliferation	IBA
negative regulation of muscle cell apoptotic process	ISO
cytokine-mediated signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	IEA
external side of plasma membrane	IBA
membrane
receptor complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
ciliary neurotrophic factor receptor activity	ISO
leukemia inhibitory factor receptor activity	ISO
oncostatin-M receptor activity	ISO
oncostatin-M receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

ciliary neurotrophic factor receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

immune receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

leukemia inhibitory factor receptor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
ciliary neurotrophic factor receptor binding
cytokine-mediated signaling pathway
oncostatin-M receptor activity
positive regulation of cell population proliferation

Displaying **all 7** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Leukemia inhibitory factor receptor, D2 domain
Leukemia inhibitory factor receptor, N-terminal
Leukemia inhibitory factor receptor-like, Ig-like domain
Long hematopoietin receptor, Gp130 family 2, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080205	CAKUT	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3977	Xenbase:XB-GENE-485214	HUMAN78945
Danio rerio	9180	ZFIN:ZDB-GENE-050327-16
Xenopus tropicalis	16880	Xenbase:XB-GENE-485214
Danio rerio	18414	ZFIN:ZDB-GENE-050327-16
Rattus norvegicus	81680	Xenbase:XB-GENE-485214	RATNO24305
Danio rerio	310132	ZFIN:ZDB-GENE-080107-2
Canis lupus familiaris	449478		CANLF14998
Bos taurus	539504		BOVIN16029
Macaca mulatta	694139		MACMU39667
Pan troglodytes	738797		PANTR35679

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements