GlyCosmos Portal

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cell projection
Cytoplasmic vesicle
Lipid-binding
Methylation
Phosphoprotein
Postsynaptic cell membrane
Protein transport
Reference proteome
Repeat
Synapse
Transport
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P47709	Exophilin-1
F1LPB9
A0A8I6A3Z9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of NMDA receptor activity	IMP	26679993
positive regulation of calcium ion-dependent exocytosis	IBA
dendritic spine organization	IMP	26679993
exocytosis	IEA
spontaneous neurotransmitter secretion	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

dendritic spine organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

postsynapse organization [inference]

dendritic spine organization

exocytic process [inference]

synaptic vesicle priming

export from cell [inference]

secretion by cell [inference]

exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion [inference]

spontaneous neurotransmitter secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion [inference]

spontaneous neurotransmitter secretion

vesicle-mediated transport [inference]

exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion [inference]

spontaneous neurotransmitter secretion

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

export from cell [inference]

secretion by cell [inference]

exocytosis

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion [inference]

spontaneous neurotransmitter secretion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

neurotransmitter secretion [inference]

spontaneous neurotransmitter secretion

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
protein-containing complex	IDA	14960300
neuromuscular junction	IDA	8060298
neuron projection	IBA
dendritic spine	IDA	26679993
extrinsic component of synaptic vesicle membrane	EXP IBA IDA	17110340 8060298

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

extrinsic component of membrane

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

presynapse

postsynapse [inference]

dendritic spine

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
small GTPase binding	IEA
phosphatidylinositol-4,5-bisphosphate binding	IDA	18945677
metal ion binding	IEA
phospholipid binding	TAS	7946335
phosphate ion binding	IDA	11640918

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

lipid binding [inference]

phospholipid binding

calcium-dependent phospholipid binding

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

selenium binding

small molecule binding [inference]

alcohol binding [inference]

inositol 1,4,5 trisphosphate binding

ion binding [inference]

anion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

rabphilin-3A

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
regulation of calcium ion-dependent exocytosis
spontaneous neurotransmitter secretion

Displaying entries **1 - 10** of 11 in total

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InterPro
C2 domain superfamily
C2 domain
FYVE-type zinc finger
Rab-binding domain
Rabphilin-3A, FYVE domain
Rabphilin/Doc2, first C2 domain
Rabphilin/Doc2/Noc2
Synaptotagmin
Zinc finger, FYVE-related
Zinc finger, FYVE/PHD-type

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
extrinsic component of membrane	PMID:7946335
protein-containing complex	PMID:14960300
synaptic vesicle membrane	PMID:7946335
secretory granule	PMID:18573236
synaptic vesicle	PMID:11466417 PMID:14960300

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0070515	chromosome 16p11.2 deletion syndrome, 593-kb	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ornithorhynchus anatinus	100075921			ORNAN16444
Pongo abelii	100173716			PONAB05424
Pongo abelii	100189915			PONAB05424
Taeniopygia guttata	100231430			TAEGU06127
Oryctolagus cuniculus	100340019			RABIT09166
Callithrix jacchus	100385003			CALJA44866
Ailuropoda melanoleuca	100467865			AILME06581
Xenopus tropicalis	100487950		Xenbase:XB-GENE-5881709
Nomascus leucogenys	100587205			NOMLE01582
Cavia porcellus	100733083	10141_0:0009ad

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements