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leucyl and cystinyl aminopeptidase

Summary

Gene Symbol

Lnpep

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171105

PubChem

171105

Alliance of Genome Resources

RGD:621752

Annotation

Keyword

Acetylation
Aminopeptidase
Cell membrane
Direct protein sequencing
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KB65
P97629	GP160 Insulin-regulated membrane aminopeptidase Insulin-responsive aminopeptidase Oxytocinase Placental leucine aminopeptidase Vesicle protein of 165 kDa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA
proteolysis	IEA
regulation of blood pressure	IBA
response to hormone	IDA	12709058
neuropeptide catabolic process	IMP	16771832

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure

positive regulation of blood pressure

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
cytoplasm	IBA
plasma membrane	ISO
plasma membrane	IDA	27881773
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
aminopeptidase activity	ISO
aminopeptidase activity	IDA	16619500 7559527
aminopeptidase activity	IMP	16619500 16771832 16967782
aminopeptidase activity	IEA
metallopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aminopeptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
perinuclear region of cytoplasm	PMID:9271094
insulin-responsive compartment	PMID:7559527 PMID:9271094
neuronal cell body	PMID:15906313
vesicle	PMID:12709058
cell surface	PMID:16967782

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Saimiri boliviensis boliviensis	101040288	SAIBB01630
Takifugu rubripes	101075332	TAKRU29498
Felis catus	101083321	FELCA02402
Ovis aries	101102729	SHEEP17064
Gorilla gorilla gorilla	101139054	GORGO32844
Oryzias latipes	101154957	ORYLA17652
Jaculus jaculus	101611160	JACJA02643
Mustela putorius furo	101682451	MUSPF05928
Ficedula albicollis	101815820	FICAL10131
Melopsittacus undulatus	101876207	MELUD16172

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Annotation

OrthoDB (Group)

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Acknowledgements