GlyCosmos Portal

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solute carrier family 6 member 5

Summary

Gene Symbol

Slc6a5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171148

PubChem

171148

Alliance of Genome Resources

RGD:621824

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Metal-binding
Neurotransmitter transport
Phosphoprotein
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P58295	Solute carrier family 6 member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycine transport	IDA	8226790
neurotransmitter uptake	ISO
sodium ion transmembrane transport	IBA
neurotransmitter reuptake	ISO
synaptic transmission, glycinergic	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

neurotransmitter transport [inference]

neurotransmitter uptake

neurotransmitter reuptake

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

neutral amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

neutral amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

neutral amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-amino acid transport [inference]

glycine transport

glycine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

glycine import across plasma membrane

import into cell [inference]

neurotransmitter uptake

neurotransmitter reuptake

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

establishment of localization in cell [inference]

neurotransmitter reuptake

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycinergic synapse	IDA ISO	19374720 7751957
plasma membrane	IBA ISO ISS
endosome	IDA	12091465
dense core granule	IDA	12091465
presynaptic membrane	IDA	19374720 7751957

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glycinergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycine transmembrane transporter activity	IDA	8226790
glycine:sodium symporter activity	IBA IDA ISO	8226790
metal ion binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

glycine transmembrane transporter activity

glycine:sodium symporter activity

L-amino acid transmembrane transporter activity [inference]

glycine transmembrane transporter activity

glycine:sodium symporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

glycine transmembrane transporter activity

glycine:sodium symporter activity

L-amino acid transmembrane transporter activity [inference]

glycine transmembrane transporter activity

glycine:sodium symporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium- and chloride-dependent glycine transporter 2

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
symporter activity
synaptic transmission, glycinergic

Displaying **all 2** entries
InterPro
Sodium
Sodium

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060698	hyperekplexia 3	Alliance of Genome Resources
DOID:11723	Duchenne muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9152		HGNC:11051	HUMAN05050
Drosophila melanogaster	37772		FB:FBgn0034911
Mus musculus	104245	10090_1:00226a	MGI:105090	MOUSE56231
Caenorhabditis elegans	191768		WB:WBGene00004905
Danio rerio	494450		ZFIN:ZDB-GENE-050105-2	DANRE40449
Canis lupus familiaris	612095			CANLF08609
Monodelphis domestica	100030555			MONDO27911
Equus caballus	100057380			HORSE40055
Ornithorhynchus anatinus	100073980			ORNAN19163
Oryctolagus cuniculus	100339626			RABIT01102

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements