GlyCosmos Portal

Submissions

7-dehydrocholesterol reductase

Summary

Gene Symbol

DHCR7

Organism

Homo sapiens (human)

External Links

NCBI Gene

1717

HGNC

2860

KEGG Gene ID

hsa:1717

PubChem

1717

Alliance of Genome Resources

HGNC:2860

Annotation

Keyword

Cholesterol biosynthesis
Disease variant
Endoplasmic reticulum
NADP
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UBM7	Delta7-sterol reductase Sterol Delta(7)-reductase Sterol reductase SR-2
A0A024R5F7	Sterol Delta(7)-reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IBA IMP	9465114
brassinosteroid biosynthetic process	IBA
cholesterol biosynthetic process via lathosterol
cholesterol biosynthetic process via desmosterol

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	9878250
endoplasmic reticulum membrane	IBA TAS
nuclear outer membrane	IDA	9878250
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

nuclear membrane [inference]

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
7-dehydrocholesterol reductase activity	EXP IBA IDA	9465114
protein binding	IPI	25637936 32694168
NADP binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

7-dehydrocholesterol reductase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000172893

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00213

Name

7-dehydrocholesterol reductase [EC:1.3.1.21]

References

9465114

Rhea

RHEA:23984

cholesterol + NADP⁺

H⁺ + 7-dehydrocholesterol + NADPH

Enzyme

1.3.1.21

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **119** in total

1

2

3

4

5

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050429	Hailey-Hailey disease	DisGeNET
DOID:0050454	periventricular nodular heterotopia	DisGeNET
DOID:0050571	congenital disorder of glycosylation type II	DisGeNET
DOID:0050651	atrioventricular septal defect	DisGeNET
DOID:0050778	Meckel syndrome	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060281	photosensitive epilepsy	DisGeNET
DOID:0060330	Rapp-Hodgkin syndrome	DisGeNET
DOID:0060336	3-methylglutaconic aciduria	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of **180** in total

1

2

3

4

5

…

Next ›

Last »
HPO ID	HPO Term
HP:0000003	Multicystic kidney dysplasia
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000046	Small scrotum
HP:0000047	Hypospadias
HP:0000048	Bifid scrotum
HP:0000054	Micropenis
HP:0000062	Ambiguous genitalia
HP:0000074	Ureteropelvic junction obstruction
HP:0000081	Duplicated collecting system

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:270400	Smith-Lemli-Opitz syndrome
ORPHA:818	Smith-Lemli-Opitz syndrome

PubChem Disease

GHR Health Conditions

Smith-Lemli-Opitz syndrome

MedGen Diseases

Smith-Lemli-Opitz syndrome

OMIM Phenotypes

SMITH-LEMLI-OPITZ SYNDROME; SLOS

KEGG Diseases

Smith-Lemli-Opitz syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002707
Gene Name: 7-dehydrocholesterol reductase

Ortholog

Displaying entries **1 - 10** of 88 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181886	WB:WBGene00007126
Drosophila melanogaster	37482	FB:FBgn0034657
Callorhinchus milii	103175009		CALMI06801
Latimeria chalumnae	102362669		LATCH13480
Danio rerio	378446	ZFIN:ZDB-GENE-030912-9
Astyanax mexicanus	103033332		ASTMX08984
Ictalurus punctatus	108271323		ICTPU00989
Electrophorus electricus	113578447		ELEEL02260
Salmo salar	106587139		SALSA113312
Salmo trutta	115167486		SALTR81497

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements