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Acetylcholine receptor subunit alpha-type unc-38

Summary

Gene Symbol

unc-38

Organism

Caenorhabditis elegans

External Links

NCBI Gene

172105

PubChem

172105

Alliance of Genome Resources

WB:WBGene00006774

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q23022	Uncoordinated protein 38

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of locomotion involved in locomotory behavior	IMP	23351035
regulation of postsynaptic membrane potential	IEA
inorganic cation transmembrane transport	IDA	8581398 9606719
excitatory postsynaptic potential	IEA
ion transmembrane transport	IBA IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

cellular response to stimulus

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

locomotion

response to stimulus [inference]

cellular response to stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

regulation of behavior [inference]

regulation of egg-laying behavior

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of reproductive process [inference]

regulation of egg-laying behavior

regulation of biological quality [inference]

regulation of membrane potential

regulation of postsynaptic membrane potential

excitatory postsynaptic potential

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GO Term	Evidence Code	PMID
membrane	IEA
postsynaptic membrane	IDA IEA	16466809
plasma membrane	IBA IEA
neuron projection	IBA IDA	16466809
acetylcholine-gated channel complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

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GO Term	Evidence Code	PMID
acetylcholine-gated monoatomic cation-selective channel activity	IBA IDA IEA	20027209
excitatory extracellular ligand-gated monoatomic ion channel activity	IDA	8581398
ion channel activity	IEA
monoatomic ion channel activity	IEA
extracellular ligand-gated monoatomic ion channel activity	IDA IEA	9606719

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

AcetylCholine Receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 5** entries
Gene Ontology
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Nicotinic acetylcholine receptor

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
neuron projection	PMID:16466809

Disease

Disease Ontology

Displaying entries **21 - 27** of 27 in total

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DO ID	Disease Name	Source
DOID:3905	lung carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:5409	lung small cell carcinoma	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:809	cocaine abuse	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 41 in total

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Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25101	RGD:2345
Rattus norvegicus	25102	RGD:2347
Rattus norvegicus	25590	RGD:2346
Drosophila melanogaster	42918	FB:FBgn0000036
Drosophila melanogaster	42919	FB:FBgn0000039
Drosophila melanogaster	42920	FB:FBgn0004118
Rattus norvegicus	79557	RGD:69277
Rattus norvegicus	81721	RGD:69281
Mus musculus	108043	MGI:106212
Mus musculus	110834	MGI:87887