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E3 ubiquitin-protein ligase hrd-like protein 1

Summary

Gene Symbol

hrdl-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

172833

PubChem

172833

Alliance of Genome Resources

WB:WBGene00009164

Annotation

Keyword

Glycoprotein
Reference proteome
Transmembrane helix
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P90859

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein K48-linked ubiquitination	IBA
multicellular organism growth	IGI	17825049
ubiquitin-dependent protein catabolic process	IBA
endoplasmic reticulum unfolded protein response	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K48-linked ubiquitination

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K48-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

multicellular organismal process [inference]

multicellular organism growth

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA
cellular_component	ND
endoplasmic reticulum	IBA
ubiquitin ligase complex	IBA
cytosol	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
ubiquitin protein ligase activity	IBA
molecular_function	ND
ubiquitin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding [inference]

ubiquitin-like protein binding [inference]

ubiquitin binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase AMFR

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ubiquitin binding

Displaying 1 entry
InterPro
Ubiquitin system component CUE

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070458	hereditary spastic paraplegia 89	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	267		HGNC:463
Mus musculus	23802		MGI:1345634
Rattus norvegicus	361367		RGD:1311551
Danio rerio	406442		ZFIN:ZDB-GENE-040426-2190
Xenopus tropicalis	549837		Xenbase:XB-GENE-923086
Brugia malayi	6100320	6279_0:0012e8
Loa loa	9943281	7209_0:0009a1
Necator americanus	25355732	51031_0:0048f1
Danio rerio	101884807		ZFIN:ZDB-GENE-130530-643