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mutL homolog 1

Summary

Gene Symbol

Mlh1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17350

PubChem

17350

Alliance of Genome Resources

MGI:101938

Annotation

Keyword

ATP-binding
Cell cycle
Chromosome
DNA repair
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JK91	MutL protein homolog 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
positive regulation of isotype switching to IgG isotypes	IMP	10430621
meiotic metaphase I homologous chromosome alignment	IMP	10385520
female meiosis chromosome segregation	IMP	25533956
resolution of meiotic recombination intermediates	IMP	10385520 12217320
somatic recombination of immunoglobulin genes involved in immune response	IGI	12743174

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

microtubule-based process [inference]

spindle midzone assembly [inference]

meiotic spindle midzone assembly

cell cycle [inference]

meiotic cell cycle

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation [inference]

meiotic chromosome segregation

spindle midzone assembly [inference]

meiotic spindle midzone assembly

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiotic chromosome segregation

meiotic spindle midzone assembly

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

chromosome organization involved in meiotic cell cycle [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

female meiosis chromosome segregation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response

isotype switching

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

intrinsic apoptotic signaling pathway in response to DNA damage

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

chromosome organization [inference]

chromosome organization involved in meiotic cell cycle [inference]

cellular component assembly [inference]

spindle midzone assembly [inference]

meiotic spindle midzone assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

female meiosis chromosome segregation

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

male gamete generation [inference]

spermatogenesis

meiotic cell cycle

chromosome localization to nuclear envelope involved in homologous chromosome segregation [inference]

meiotic telomere clustering

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiotic chromosome segregation

meiotic spindle midzone assembly

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

chromosome organization involved in meiotic cell cycle [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

biological phase [inference]

cell cycle phase [inference]

meiotic cell cycle phase [inference]

meiosis I cell cycle phase [inference]

leptotene

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

intrinsic apoptotic signaling pathway in response to DNA damage

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

mismatch repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

intrinsic apoptotic signaling pathway in response to DNA damage

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

chromosome localization to nuclear envelope involved in homologous chromosome segregation [inference]

meiotic telomere clustering

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

chromosome localization to nuclear envelope involved in homologous chromosome segregation [inference]

meiotic telomere clustering

organelle localization [inference]

chromosome localization [inference]

telomere localization [inference]

meiotic telomere clustering

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

chromosome localization to nuclear envelope involved in homologous chromosome segregation [inference]

meiotic telomere clustering

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

meiotic metaphase chromosome alignment [inference]

meiotic metaphase I homologous chromosome alignment

chromosome localization to nuclear envelope involved in homologous chromosome segregation [inference]

meiotic telomere clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination [inference]

negative regulation of mitotic recombination

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination [inference]

negative regulation of mitotic recombination

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination [inference]

negative regulation of mitotic recombination

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination [inference]

negative regulation of mitotic recombination

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of developmental process [inference]

positive regulation of isotype switching [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of isotype switching [inference]

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of isotype switching [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination [inference]

negative regulation of mitotic recombination

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of isotype switching [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA recombination [inference]

positive regulation of isotype switching [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination [inference]

negative regulation of mitotic recombination

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

positive regulation of isotype switching [inference]

regulation of isotype switching to IgA isotypes [inference]

positive regulation of isotype switching to IgA isotypes

regulation of isotype switching to IgG isotypes [inference]

positive regulation of isotype switching to IgG isotypes

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation [inference]

positive regulation of isotype switching [inference]

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GO Term	Evidence Code	PMID
late recombination nodule	IDA	27760146
condensed chromosome	IDA IMP	12091911 12913077 8673133
male germ cell nucleus	IDA	17696610
nucleoplasm	ISO TAS
synaptonemal complex	IDA ISS	15467367 16260499 16968740

GO Hierarchy

cellular component

protein-containing complex [inference]

mismatch repair complex [inference]

MutLalpha complex

nuclear protein-containing complex [inference]

MutLalpha complex

cellular anatomical entity [inference]

recombination nodule [inference]

late recombination nodule

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

synaptonemal structure [inference]

synaptonemal complex

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GO Term	Evidence Code	PMID
enzyme binding	IEA ISO
chromatin binding	IDA ISO	14716311
ATP hydrolysis activity	IBA IEA
MutSalpha complex binding	IEA ISO
guanine/thymine mispair binding	IGI ISO	16713580

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

mismatch repair complex binding [inference]

MutSalpha complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

mismatched DNA binding [inference]

guanine/thymine mispair binding

single-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

small molecule sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

DNA mismatch repair protein Mlh1

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity
DNA repair
somatic hypermutation of immunoglobulin genes

Displaying **all 8** entries
InterPro
DNA mismatch repair protein Mlh1, C-terminal
DNA mismatch repair protein MutL/Mlh/PMS
DNA mismatch repair protein MutL/Mlh/Pms-like
DNA mismatch repair protein, S5 domain 2-like
DNA mismatch repair, conserved site
Histidine kinase/HSP90-like ATPase superfamily
Ribosomal protein uS5 domain 2-type superfamily
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0050465	Muir-Torre syndrome	Alliance of Genome Resources
DOID:0070274	hereditary nonpolyposis colorectal cancer type 2	Alliance of Genome Resources
DOID:0112182	mismatch repair cancer syndrome	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:2876	laryngeal squamous cell carcinoma	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources
DOID:3905	lung carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4292		HGNC:7127	HUMAN69139
Drosophila melanogaster	35796		FB:FBgn0011659
Rattus norvegicus	81685	10116_1:002c85	RGD:620937	RATNO40959
Caenorhabditis elegans	176783		WB:WBGene00003373
Danio rerio	393632		ZFIN:ZDB-GENE-040426-1600	DANRE05720
Canis lupus familiaris	477019			CANLF08940
Bos taurus	533652			BOVIN17231
Macaca mulatta	698782			MACMU28146
Pan troglodytes	747104			PANTR30744
Saccharomyces cerevisiae S288C	855203		SGD:S000004777

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements