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macrophage expressed gene 1

Summary

Gene Symbol

Mpeg1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17476

PubChem

17476

Alliance of Genome Resources

MGI:1333743

Annotation

Keyword

3D-structure
Adaptive immunity
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Innate immunity
Proteomics identification
Reference proteome
Signal
Transmembrane beta strand
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QN37	Perforin-2
A1L314	Perforin-2 Protein MPS1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
dendritic cell antigen processing and presentation	IDA	37347855
antigen processing and presentation of exogenous peptide antigen	IDA	35471730
antigen processing and presentation of exogenous peptide antigen via MHC class I	IDA	37347855
defense response to bacterium	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

innate immune response [inference]

antibacterial innate immune response

antigen processing and presentation [inference]

dendritic cell antigen processing and presentation

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen

antigen processing and presentation of exogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class I

antigen processing and presentation of exogenous peptide antigen

antigen processing and presentation of exogenous peptide antigen via MHC class I

cellular process [inference]

transmembrane transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

antibacterial innate immune response

immune response [inference]

adaptive immune response

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

antibacterial innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
phagocytic vesicle membrane	IDA	37347855
cytoplasmic vesicle	ISO
cytoplasmic vesicle	IDA	26402460
endolysosome	IDA	35471730
phagocytic vesicle	IDA	26402460

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

phagolysosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

phagolysosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

phagolysosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
wide pore channel activity	ISO
wide pore channel activity	IDA	32064340 36245269 37347855
pore-forming activity	IDA	26402460

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

wide pore channel activity

pore-forming activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

macrophage expressed 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adaptive immune response

Displaying **all 2** entries
InterPro
Macrophage-expressed gene 1 protein
Membrane attack complex component/perforin (MACPF) domain

Ortholog

Displaying entries **41 - 50** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Astyanax mexicanus	103034161	ASTMX15629
Astyanax mexicanus	103035131	ASTMX15630
Poecilia formosa	103135412	POEFO04132
Poecilia formosa	103135414	POEFO04136
Poecilia formosa	103135421	POEFO04142
Callorhinchus milii	103172239	CALMI46710
Callorhinchus milii	103190686	CALMI44173
Chlorocebus sabaeus	103234994	CHLSB00383
Ursus maritimus	103666145	URSMA27800
Rhinopithecus roxellana	104679443	RHIRO09259

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements