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myeloperoxidase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17523

PubChem

17523

Alliance of Genome Resources

MGI:97137

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Lysosome
Oxidation
Oxidoreductase
Reference proteome
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P11247
Q7TMS4
Q571G0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
hypochlorous acid biosynthetic process	IMP	10085024
response to gold nanoparticle	IEA
removal of superoxide radicals	IMP	10085024
hydrogen peroxide catabolic process	IDA IMP ISO	10085024
response to mechanical stimulus	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

respiratory burst involved in defense response

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

hypochlorous acid biosynthetic process

reactive oxygen species biosynthetic process [inference]

hypochlorous acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species biosynthetic process [inference]

hypochlorous acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

small molecule biosynthetic process [inference]

hypochlorous acid biosynthetic process

respiratory burst [inference]

respiratory burst involved in defense response

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hypochlorous acid metabolic process [inference]

hypochlorous acid biosynthetic process

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species biosynthetic process [inference]

hypochlorous acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to other organism [inference]

defense response to bacterium

defense response to Gram-positive bacterium

defense response to fungus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

defense response to Gram-positive bacterium

defense response to fungus

response to oxidative stress

response to external stimulus [inference]

response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to food

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to other organism [inference]

defense response to bacterium

defense response to Gram-positive bacterium

defense response to fungus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to other organism [inference]

defense response to bacterium

defense response to Gram-positive bacterium

defense response to fungus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to food

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to transition metal nanoparticle [inference]

response to gold nanoparticle

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
secretory granule	ISO
intracellular membrane-bounded organelle	ISO
azurophil granule	ISO ISS
nucleoplasm	IEA ISO
mitochondrion	HDA	14651853

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
heparin binding	ISO
metal ion binding	IEA
peroxidase activity	IBA IDA IMP ISO	10085024 11792727 11980719 15159534
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

myeloperoxidase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080348	Alzheimer's disease 1	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources
DOID:161	keratosis	Alliance of Genome Resources
DOID:1679	cystitis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **134** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4353		HGNC:7218	HUMAN35225
Drosophila melanogaster	38326		FB:FBgn0011828
Drosophila melanogaster	42100		FB:FBgn0038511
Drosophila melanogaster	42681		FB:FBgn0263986
Caenorhabditis elegans	181288		WB:WBGene00004257
Caenorhabditis elegans	191484		WB:WBGene00004256
Rattus norvegicus	303413	10116_1:00350b	RGD:1592081	RATNO03576
Danio rerio	337514		ZFIN:ZDB-GENE-030131-9460	DANRE00843
Bos taurus	511206			BOVIN12141
Canis lupus familiaris	609986			CANLF18942