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deleted in malignant brain tumors 1

Summary

Gene Symbol

DMBT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1755

PubChem

1755

Alliance of Genome Resources

HGNC:2926

Annotation

Keyword

3D-structure
Alternative splicing
Antiviral defense
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Protein transport
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Tumor suppressor

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UGM3	Glycoprotein 340 Hensin Salivary agglutinin Surfactant pulmonary-associated D-binding protein
A0A590UJ76	Hensin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
induction of bacterial agglutination	IDA IMP TAS	11007786 14732920 19189310
protein transport	IEA
vesicle-mediated transport	IEA
receptor-mediated endocytosis	IDA	19189310
defense response to Gram-negative bacterium	IMP ISS	11007786

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

cellular process [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

defense response to symbiont [inference]

defense response to virus

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

defense response to symbiont [inference]

defense response to virus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IBA ISS
extracellular region	TAS	14732920
zymogen granule membrane	ISS
extracellular space	HDA IDA	11007786 19189310 22664934
cytoplasm	IDA	10485905

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

zymogen granule membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

zymogen granule membrane

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10101009 14676191 22811680
scavenger receptor activity	IDA NAS TAS	10485905 19189310 9288095
DNA binding	IDA	19189310
zymogen binding	ISS
calcium-dependent protein binding	TAS	10485905

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

zymogen binding

calcium-dependent protein binding

lipid binding [inference]

lipopolysaccharide binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

glycosaminoglycan binding [inference]

heparan sulfate binding

lipoteichoic acid binding

sulfur compound binding [inference]

heparan sulfate binding

cargo receptor activity [inference]

scavenger receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

scavenger receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
SRCR domain
SRCR-like domain superfamily
SRCR-like domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050771	pheochromocytoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources

Ortholog

Displaying **all 8** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12945		MGI:106210	MOUSE55586
Rattus norvegicus	170568		RGD:61984	RATNO17937
Pan troglodytes	466221	9598_0:002ab6
Xenopus tropicalis	100216258		Xenbase:XB-GENE-6000361
Pongo abelii	100438168	9601_0:002a98
Pan paniscus	100975652	9597_0:002ad1
Gorilla gorilla gorilla	101129226	9595_0:002f4f
Pongo pygmaeus	129045090	9600_0:002a24