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Guidelines

MIRAGE

sarcosine dehydrogenase

Summary

Gene Symbol

SARDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

1757

PubChem

1757

Alliance of Genome Resources

HGNC:10536

Annotation

Keyword

Acetylation
Alternative splicing
Disease variant
FAD
Mitochondrion
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K596
Q9UL12	BPR-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
sarcosine catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

sarcosine metabolic process [inference]

sarcosine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

sarcosine metabolic process [inference]

sarcosine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

sarcosine metabolic process [inference]

sarcosine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid metabolic process [inference]

sarcosine metabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid catabolic process [inference]

sarcosine catabolic process

sarcosine metabolic process [inference]

sarcosine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

sarcosine catabolic process

alpha-amino acid catabolic process [inference]

sarcosine catabolic process

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
cytoplasm	IBA
mitochondrion	ISS
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
sarcosine dehydrogenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [inference]

sarcosine dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 7** entries
InterPro
Aminomethyltransferase, folate-binding domain
FAD dependent oxidoreductase, central domain
FAD dependent oxidoreductase
FAD/NAD(P)-binding domain superfamily
GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Glycine cleavage T-protein, C-terminal barrel domain
Glycine cleavage T-protein/YgfZ, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112307	sarcosinemia	Alliance of Genome Resources

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Last updated: December 8, 2025