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putative E3 ubiquitin-protein ligase plr-1

Summary

Gene Symbol

plr-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

176575

PubChem

176575

Alliance of Genome Resources

WB:WBGene00023404

Annotation

Keyword

Cell membrane
Cell projection
Endosome
Glycoprotein
Reference proteome
Signal
Transferase
Transmembrane helix
Ubl conjugation
Ubl conjugation pathway
Wnt signaling pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9U2B7	Probable E3 ubiquitin-protein transferase plr-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of Wnt signaling pathway	IMP	24401370
Wnt signaling pathway	IEA
protein ubiquitination	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
early endosome	IDA IEA	24401370
Golgi apparatus	IDA	24401370
late endosome	IDA IEA	24401370
perikaryon	IEA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
transferase activity	IEA
ubiquitin-protein transferase activity	ISS	24401370

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Zinc finger (C3HC4-type RING finger) family protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
late endosome	PMID:24401370
endosome	PMID:25448694
early endosome	PMID:24401370
cytoplasm	PMID:25448694
Golgi apparatus	PMID:24401370
neuron projection	PMID:25448694
neuronal cell body	PMID:25448694

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050869	villous adenoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:218	ascending colon cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4928	intrahepatic cholangiocarcinoma	Alliance of Genome Resources
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 13 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	54894		HGNC:18505
Homo sapiens	84133		HGNC:18126
Mus musculus	207742		MGI:2442609
Rattus norvegicus	303412		RGD:1305204
Danio rerio	556813		ZFIN:ZDB-GENE-070705-263
Xenopus tropicalis	780325		Xenbase:XB-GENE-5937936
Brugia malayi	6097336	6279_0:000975
Loa loa	9952193	7209_0:0030b7
Loa loa	9953280	7209_0:0037df
Loa loa	9953645	7209_0:003952

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Last updated: December 9, 2024