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deoxyribonuclease 1

Summary

Gene Symbol

DNASE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1773

PubChem

1773

Alliance of Genome Resources

HGNC:2956

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Apoptosis
Calcium
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Nucleus
Pharmaceutical
Reference proteome
Secreted
Signal
Systemic lupus erythematosus

Proteins

Displaying 1 entry
UniProt	Protein Name
P24855	Deoxyribonuclease I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process	IEA
DNA catabolic process	IBA ISS	29191910
regulation of neutrophil mediated cytotoxicity	ISS	29191910
neutrophil activation involved in immune response	ISS	29191910
regulation of acute inflammatory response	ISS	29191910

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

regulation of neutrophil mediated cytotoxicity

regulation of myeloid leukocyte mediated immunity [inference]

regulation of neutrophil mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

regulation of neutrophil mediated cytotoxicity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zymogen granule	IEA
extracellular region	TAS	2349940
nuclear envelope	IEA
nucleus	IBA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12849983
actin binding	IEA
DNA binding	IBA
deoxyribonuclease I activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Deoxyribonuclease I

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA catabolic process
catalytic activity
deoxyribonuclease I activity
hydrolase activity
nuclease activity

Displaying **all 3** entries
InterPro
Deoxyribonuclease I
Endonuclease/exonuclease/phosphatase superfamily
Endonuclease/exonuclease/phosphatase

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060643	primary sclerosing cholangitis	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13419		MGI:103157	MOUSE18845
Rattus norvegicus	25633		RGD:2510	RATNO00684
Bos taurus	282217			BOVIN20185
Sus scrofa	397051			PIGXX21020
Canis lupus familiaris	403413			CANLF16626
Danio rerio	436947		ZFIN:ZDB-GENE-040718-423	DANRE30870
Pan troglodytes	453867	9598_0:003fdd		PANTR11610
Macaca mulatta	704119			MACMU27209
Oryctolagus cuniculus	100009513			RABIT16769
Monodelphis domestica	100013962			MONDO30447

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements