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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
dynein cytoplasmic 1 heavy chain 1
Summary
- Gene Symbol
-
- DYNC1H1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Charcot-Marie-Tooth disease
- Coiled coil
- Cytoskeleton
- Disease variant
- Dynein
- Intellectual disability
- Microtubule
- Mitosis
- Motor protein
- Neurodegeneration
- Phosphoprotein
- Reference proteome
- Repeat
- Transport
- Proteins
| UniProt | Protein Name |
|---|---|
| Q14204 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| establishment of spindle localization | ||
| cytoplasmic microtubule organization | ||
| nuclear migration | ||
| regulation of mitotic spindle organization | ||
| retrograde axonal transport |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| microtubule | ||
| dynein complex | ||
| membrane | ||
| cell cortex | ||
| extracellular region |
| GO Term | Evidence Code | PMID |
|---|---|---|
| minus-end-directed microtubule motor activity | ||
| protein binding | ||
| dynein intermediate chain binding | ||
| ATP hydrolysis activity | ||
| dynein light intermediate chain binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Dynein heavy chain
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| dynein intermediate chain binding |
| dynein light intermediate chain binding |
| microtubule-based movement |
| minus-end-directed microtubule motor activity |
| nucleotide binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050453 | lissencephaly | |
| DOID:0050557 | congenital muscular dystrophy | |
| DOID:0070043 | autosomal dominant intellectual developmental disorder 13 | |
| DOID:0070351 | spinal muscular atrophy with lower extremity predominant 1 | |
| DOID:0110175 | Charcot-Marie-Tooth disease axonal type 2O | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1289 | neurodegenerative disease | |
| DOID:1826 | epilepsy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 13424 | MGI:103147 | MOUSE07695 | ||
| 29489 | RGD:2511 | RATNO36802 | ||
| 38580 | FB:FBgn0261797 | |||
| 172041 | WB:WBGene00000962 | |||
| 335110 | ZFIN:ZDB-GENE-030131-7050 | |||
| 453171 | 9598_0:003c78 | PANTR09567 | ||
| 480437 | CANLF18229 | |||
| 537748 | BOVIN17036 | |||
| 718989 | MACMU40061 | |||
| 853928 | SGD:S000001762 |
