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MIRAGE

myosin, heavy polypeptide 4, skeletal muscle

Summary

Gene Symbol

Myh4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17884

PubChem

17884

Alliance of Genome Resources

MGI:1339713

Annotation

Keyword

3D-structure
ATP-binding
Actin-binding
Calmodulin-binding
Coiled coil
Cytoplasm
Methylation
Myosin
Phosphoprotein
Protein transport
Reference proteome
Thick filament

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5SX39	Myosin heavy chain 2b Myosin heavy chain 4
Q3UUB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
muscle contraction	ISO
muscle contraction	IBA
response to muscle activity	IDA	18310078
protein transport

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

response to stimulus [inference]

response to activity [inference]

response to muscle activity

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
myosin complex	IEA
myosin II complex	IBA
myofibril	ISO
myofibril	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin II complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament

contractile fiber [inference]

myofibril

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
microfilament motor activity	IBA
double-stranded RNA binding	ISO	21266579
cytoskeletal motor activity	IEA
calmodulin binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin a

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 3** entries
InterPro
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of **266** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4619	Xenbase:XB-GENE-989276
Homo sapiens	4622		HUMAN31780
Saccharomyces cerevisiae S288C	4625	SGD:S000001065
Saccharomyces cerevisiae S288C	4627	SGD:S000001065
Saccharomyces cerevisiae S288C	4628	SGD:S000001065
Saccharomyces cerevisiae S288C	4629	SGD:S000001065
Danio rerio	8735	ZFIN:ZDB-GENE-081124-1
Xenopus tropicalis	17879	Xenbase:XB-GENE-989276
Xenopus tropicalis	17882	Xenbase:XB-GENE-989276
Danio rerio	17883	ZFIN:ZDB-GENE-081124-1

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Last updated: April 7, 2025