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Alpha-(1,6)-fucosyltransferase

Summary

Gene Symbol

fut-8

Organism

Caenorhabditis elegans

External Links

NCBI Gene

178985

KEGG Gene ID

cel:CELE_C10F3.6

PubChem

178985

Alliance of Genome Resources

WB:WBGene00001508

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Magnesium
Manganese
Metal-binding
Reference proteome
SH3 domain
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EFE7	Fucosyltransferase 8 GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
N-glycan fucosylation	IBA
fucosylation	IDA IGI	23754284 26002521 26538210
protein glycosylation	IEA
protein N-linked glycosylation	IBA IDA	15604090

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

glycosylation [inference]

fucosylation

N-glycan fucosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IEA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
alpha-(1->6)-fucosyltransferase activity	IBA IDA	15604090
metal ion binding	IEA
glycoprotein 6-alpha-L-fucosyltransferase activity	IDA IEA	23754284
glycosyltransferase activity	IEA
galactoside 6-L-fucosyltransferase activity	IDA	23754284

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

fucosyltransferase activity

alpha-(1->6)-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein 6-alpha-L-fucosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
N-glycan fucosylation
alpha-(1->6)-fucosyltransferase activity
hexosyltransferase activity
protein N-linked glycosylation
transferase activity

Displaying **all 5** entries
InterPro
Alpha-(1,6)-fucosyltransferase, N- and catalytic domain
Alpha-(1,6)-fucosyltransferase, SH3 domain
Glycosyltransferase family 23 (GT23) domain
SH3 domain
SH3-like domain superfamily

KEGG BRITE Database

Orthology

K00717

Name

glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]

References

8910378

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R09319	2.4.1.68	G61751GZ	G07483YN
R05988	2.4.1.68	G39213VZ	G80858MF

Rhea

RHEA:12985

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.68

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP008008
Gene Name: Protein FUT-8

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2530		HGNC:4019
Drosophila melanogaster	32122		FB:FBgn0030327
Mus musculus	53618		MGI:1858901
Xenopus tropicalis	407913		Xenbase:XB-GENE-954943
Rattus norvegicus	432392		RGD:1303096
Danio rerio	797512		ZFIN:ZDB-GENE-031118-20
Brugia malayi	6099361	6279_0:001997
Loa loa	9944142	7209_0:001bd8
Necator americanus	25343083	51031_0:0024f5
Necator americanus	25343084	51031_0:0024db

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements