GlyCosmos Portal

Submissions

Dopamine receptor 2

Summary

Gene Symbol

dop-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179347

PubChem

179347

Alliance of Genome Resources

WB:WBGene00001053

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
E7EM37	Dopamine D2-like receptor dop-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
synaptic transmission, dopaminergic	IEA
G protein-coupled receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
dopamine receptor signaling pathway	IMP	19609300
dopamine receptor signaling pathway	IGI	19609300

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

signal transduction [inference]

G protein-coupled receptor signaling pathway

dopamine receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

male mating behavior [inference]

multicellular organismal process [inference]

behavior [inference]

reproductive behavior [inference]

mating behavior [inference]

male mating behavior [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to food

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine [inference]

cellular response to amphetamine

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to food

response to nicotine [inference]

cellular response to nicotine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine [inference]

cellular response to amphetamine

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

dopamine receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

regulation of male mating behavior

positive regulation of male mating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of reproductive process [inference]

regulation of male mating behavior

positive regulation of male mating behavior

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
membrane	IEA
dendrite	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	19609300
G protein-coupled receptor activity	IEA
G protein-coupled serotonin receptor activity	IBA
protein binding	IPI	22280843 25474638
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

neurotransmitter receptor activity

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytoplasm	PMID:12887685
nucleus	PMID:12887685

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 11 in total

1

2

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Danio rerio	1813	ZFIN:ZDB-GENE-030910-2
Danio rerio	1814	ZFIN:ZDB-GENE-021119-1
Xenopus tropicalis	1815	Xenbase:XB-GENE-990215
Danio rerio	13489	ZFIN:ZDB-GENE-030910-2
Danio rerio	13490	ZFIN:ZDB-GENE-021119-1
Xenopus tropicalis	13491	Xenbase:XB-GENE-990215
Danio rerio	24318	ZFIN:ZDB-GENE-030910-2
Danio rerio	29238	ZFIN:ZDB-GENE-021119-1
Xenopus tropicalis	33007	Xenbase:XB-GENE-990215
Xenopus tropicalis	179347	Xenbase:XB-GENE-990215