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neural cell adhesion molecule 1

Summary

Gene Symbol

Ncam1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17967

PubChem

17967

Alliance of Genome Resources

MGI:97281

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Heparin-binding
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
E9Q589
A0A0A6YY47
E9QB01
P13595

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
multicellular organismal response to stress	ISO
regulation of protein phosphorylation	ISO
response to xenobiotic stimulus	ISO
calcium-mediated signaling	IDA	7613634
cell surface receptor signaling pathway	IDA	7613634

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

homotypic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell development [inference]

neuron development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance [inference]

commissural neuron axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal response to stress

developmental process [inference]

anatomical structure development [inference]

thalamus development

cell development [inference]

neuron development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell development [inference]

neuron development

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to lead ion

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of vesicle docking [inference]

regulation of exocyst assembly

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

regulation of programmed cell death [inference]

negative regulation of programmed cell death

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of exocyst assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of exocyst assembly

regulation of vesicle docking [inference]

regulation of exocyst assembly

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA ISO	17213291 21708977 7613634
Schaffer collateral - CA1 synapse	ISO
membrane
postsynaptic membrane	ISO
neuronal cell body	IDA ISO	15065125

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

anchoring junction [inference]

cell-cell junction

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

myelin sheath

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10772929 21389209 26651291 28098160 35771867
heparin binding	IEA
phosphatase binding	ISO
LRR domain binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding

protein domain specific binding [inference]

LRR domain binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neural cell adhesion molecule 1

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neural cell adhesion

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0050933	ovarian serous carcinoma	Alliance of Genome Resources
DOID:0060318	acute promyelocytic leukemia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11206	opioid abuse	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4684		HGNC:7656	HUMAN09389
Rattus norvegicus	24586	10116_1:0030be	RGD:67378	RATNO40259
Danio rerio	30447		ZFIN:ZDB-GENE-990415-31	DANRE21305
Drosophila melanogaster	31364		FB:FBgn0000635
Danio rerio	114442		ZFIN:ZDB-GENE-010822-2
Caenorhabditis elegans	180418		WB:WBGene00017184
Pan troglodytes	466782			PANTR04345
Canis lupus familiaris	479435			CANLF15281
Felis catus	493956			FELCA24216
Macaca mulatta	693789			MACMU11106

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements