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Cathepsin L-like

Summary

Gene Symbol

cpl-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

180111

PubChem

180111

Alliance of Genome Resources

WB:WBGene00000776

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O45734

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
lipid droplet disassembly	IMP	26773047
regulation of protein processing	IMP	15456850 24829385
proteolysis involved in protein catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet disassembly

organelle disassembly [inference]

lipid droplet disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

lipid droplet disassembly

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vitellogenesis

positive regulation of reproductive process [inference]

positive regulation of vitellogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptosis involved in tissue homeostasis

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vitellogenesis

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

regulation of reproductive process [inference]

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

positive regulation of reproductive process [inference]

positive regulation of vitellogenesis

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
yolk granule	IDA	15456850 16857685
vesicle lumen	IDA	15456850
endosome	IEA
endolysosome	IDA	22768338
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen

yolk granule

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

phagolysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

phagolysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26780296
cysteine-type endopeptidase activity	IBA IEA
cysteine-type peptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
annuli extracellular matrix	PMID:11707440
endolysosome	PMID:22768338
phagolysosome	PMID:24829385
collagen and cuticulin-based cuticle extracellular matrix	PMID:11707440
lysosome	PMID:24829385

Disease

Disease Ontology

Displaying entry **11 - 11** of 11 in total

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DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 50 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	498689		RGD:1564827
Rattus norvegicus	498691		RGD:1560071
Danio rerio	564835		ZFIN:ZDB-GENE-121214-37
Danio rerio	567623		ZFIN:ZDB-GENE-080215-7
Rattus norvegicus	680718		RGD:1588248
Brugia malayi	6098668	6279_0:00120d
Brugia malayi	6098898	6279_0:00198a
Brugia malayi	6098899	6279_0:001b6b
Brugia malayi	6099385	6279_0:00173f
Brugia malayi	6105609	6279_0:001a5e

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Last updated: December 9, 2024