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diphthamide biosynthesis 2

Summary

Gene Symbol

DPH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1802

PubChem

1802

Alliance of Genome Resources

HGNC:3004

Annotation

Keyword

Acetylation
Alternative splicing
Disease variant
Dwarfism
Ectodermal dysplasia
Hypotrichosis
Intellectual disability
Iron-sulfur
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KRB8
Q9BQC3	Diphthamide biosynthesis protein 2 Diphtheria toxin resistance protein 2 S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein histidyl modification to diphthamide	ISS
protein histidyl modification to diphthamide	TAS
protein histidyl modification to diphthamide	IMP	32576952
protein histidyl modification to diphthamide	IBA
protein histidyl modification to diphthamide	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32296183
metal ion binding	IEA
4 iron, 4 sulfur cluster binding	ISS
2-(3-amino-3-carboxypropyl)histidine synthase activity	ISS
2-(3-amino-3-carboxypropyl)histidine synthase activity	EXP	20559380

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

2-(3-amino-3-carboxypropyl)histidine synthase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
2-(3-amino-3-carboxypropyl)histidine synthase activity
iron-sulfur cluster binding
metal ion binding
protein histidyl modification to diphthamide

Displaying **all 4** entries
InterPro
Diphthamide synthesis DHP2
Diphthamide synthesis DPH1/DPH2, domain 1
Diphthamide synthesis DPH1/DPH2, domain 3
Diphthamide synthesis DPH1/DPH2

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070478	diphthamide deficiency syndrome 2	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Papio anubis	101012413	PAPAN19655
Saimiri boliviensis boliviensis	101040713	SAIBB27633
Takifugu rubripes	101068330	TAKRU01542
Felis catus	101084123	FELCA20430
Ovis aries	101113967	SHEEP00229
Gorilla gorilla gorilla	101134162	GORGO18101
Oryzias latipes	101167249	ORYLA08942
Tursiops truncatus	101317047	TURTR08674
Octodon degus	101577975	OCTDE26307
Jaculus jaculus	101598067	JACJA24589

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OrthoDB (Group)

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Acknowledgements