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Netrin unc-6

Summary

Gene Symbol

unc-6

Organism

Caenorhabditis elegans

External Links

NCBI Gene

180961

PubChem

180961

Alliance of Genome Resources

WB:WBGene00006746

Annotation

Keyword

3D-structure
Basement membrane
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Neurogenesis
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P34710	Uncoordinated protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
regulation of sensory neuron axon guidance	IGI	18434533
regulation of cell migration	IGI IMP	10864868
regulation of motor neuron axon guidance	IGI	18434533
establishment or maintenance of actin cytoskeleton polarity	IMP	30045855
nematode male tail tip morphogenesis	IMP	24004945

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesodermal cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

dendrite development

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

gonad morphogenesis

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

gonad morphogenesis

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis

gonad morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure development [inference]

animal organ development [inference]

ventral cord development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of anterior/posterior axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of anterior/posterior axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of axon guidance [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of anterior/posterior axon guidance [inference]

positive regulation of anterior/posterior axon guidance

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance [inference]

positive regulation of anterior/posterior axon guidance

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying **all 4** entries
GO Term	Evidence Code	PMID
basement membrane	IBA IDA IEA	19098902
extracellular region	IEA
axon	IDA	8562088
cytoplasm	IDA	8562088

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying 1 entry
GO Term	Evidence Code	PMID
signaling receptor binding	ISS	8861903

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Netrin-1

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
animal organ morphogenesis
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 5** entries
InterPro
Laminin, N-terminal
Laminin-type EGF domain
Netrin domain
Netrin module, non-TIMP type
Tissue inhibitor of metalloproteinases-like, OB-fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
basement membrane	PMID:19098902

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111153	congenital mirror movement disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 18 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	4917	HGNC:8030
Homo sapiens	9423	HGNC:8029
Mus musculus	18208	MGI:105088
Mus musculus	18209	MGI:1341188
Danio rerio	30192	ZFIN:ZDB-GENE-990415-168
Danio rerio	30227	ZFIN:ZDB-GENE-990415-169
Drosophila melanogaster	32398	FB:FBgn0015773
Drosophila melanogaster	32400	FB:FBgn0015774
Rattus norvegicus	114523	RGD:619809
Rattus norvegicus	114524	RGD:619811

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements