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Carboxylesterase type B domain-containing protein;Neuroligin-1

Summary

Gene Symbol

nlg-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

181484

PubChem

181484

Alliance of Genome Resources

WB:WBGene00006412

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 7** entries
UniProt	Protein Name
Q9XTG1
A0A0K3AT91
A0A0K3AT61
A0A0K3AVK6
A0A0K3AVG1
G5EED7
G5ECG6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
presynaptic membrane assembly	IBA
neuron cell-cell adhesion	IBA
retinol metabolic process	IEA
modulation of chemical synaptic transmission	IBA
postsynaptic membrane assembly	IBA

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion

cell-cell adhesion [inference]

neuron cell-cell adhesion

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

membrane assembly [inference]

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

presynaptic membrane organization [inference]

presynaptic membrane assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IEA
presynapse	IEA
plasma membrane	HDA IBA IEA	21611156
cell surface	IBA
dendrite	IDA	18255029

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

presynapse

Displaying **all 2** entries
GO Term	Evidence Code	PMID
neurexin family protein binding	IBA
signaling receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

neurexin family protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxylesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase, type B

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
postsynapse	PMID:26028574
muscle cell projection	PMID:21611156
plasma membrane	PMID:21611156
synapse	PMID:18255029 PMID:20083577 PMID:21611156 PMID:25232106 PMID:26028575
neuromuscular junction	PMID:26028574
dendrite	PMID:18255029 PMID:22859820
synaptic vesicle	PMID:22859820
axon	PMID:22859820

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	22829	HGNC:15529
Homo sapiens	22871	HGNC:14291
Drosophila melanogaster	33962	FB:FBgn0031866
Drosophila melanogaster	40912	FB:FBgn0083963
Drosophila melanogaster	40913	FB:FBgn0051146
Drosophila melanogaster	42402	FB:FBgn0083975
Homo sapiens	54413	HGNC:14289
Homo sapiens	57502	HGNC:14287
Homo sapiens	57555	HGNC:14290
Rattus norvegicus	116647	RGD:621117