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Degenerin mec-4

Summary

Gene Symbol

mec-4

Organism

Caenorhabditis elegans

External Links

NCBI Gene

181728

PubChem

181728

Alliance of Genome Resources

WB:WBGene00003168

Annotation

Keyword

3D-structure
Cell projection
Glycoprotein
Neurodegeneration
Potassium transport
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P24612	Mechanosensory abnormality protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
detection of mechanical stimulus involved in sensory perception of touch	IGI IMP	8692859
positive regulation of mechanosensory behavior	IGI	8692859
sodium ion transport	IEA
mechanosensory behavior	IGI IMP	7227647 8692859
ion transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

behavior [inference]

mechanosensory behavior

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

regulation of detection of mechanical stimulus involved in sensory perception of touch [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

regulation of mechanosensory behavior [inference]

positive regulation of mechanosensory behavior

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

regulation of sensory perception [inference]

regulation of detection of mechanical stimulus involved in sensory perception of touch [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of mechanosensory behavior [inference]

positive regulation of mechanosensory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of reproductive process [inference]

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IDA IEA	8655580
plasma membrane	IBA
cell projection	IEA
axon	IDA IEA	24567339
neuron projection membrane	IDA	18094248

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane

leading edge membrane [inference]

neuron projection membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sodium channel activity	IEA
ion channel activity	IEA
monoatomic ion channel activity	IEA
ligand-gated sodium channel activity	IBA IDA	12478294 18670436 26941331

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ligand-gated sodium channel activity
monoatomic ion transport
sodium channel activity
sodium ion transmembrane transport

Displaying 1 entry
InterPro
Epithelial sodium channel

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
neuronal cell body	PMID:18094248
axon	PMID:18385318
dendrite	PMID:31995033
neuron projection membrane	PMID:18094248

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0050477	Liddle syndrome	Alliance of Genome Resources
DOID:0060854	autosomal recessive pseudohypoaldosteronism type 1	Alliance of Genome Resources
DOID:0080526	bronchiectasis 1	Alliance of Genome Resources
DOID:0080527	bronchiectasis 2	Alliance of Genome Resources
DOID:0080528	bronchiectasis 3	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:326	ischemia	Alliance of Genome Resources
DOID:4479	pseudohypoaldosteronism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 21 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	6337	HGNC:10599
Homo sapiens	6338	HGNC:10600
Homo sapiens	6339	HGNC:10601
Homo sapiens	6340	HGNC:10602
Mus musculus	20276	MGI:101782
Mus musculus	20277	MGI:104696
Mus musculus	20278	MGI:104695
Rattus norvegicus	24767	RGD:3640
Rattus norvegicus	24768	RGD:3641
Rattus norvegicus	25122	RGD:3639