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DS cell adhesion molecule

Summary

Gene Symbol

DSCAM

Organism

Homo sapiens (human)

External Links

NCBI Gene

1826

PubChem

1826

Alliance of Genome Resources

HGNC:3039

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60469	CHD2 Down syndrome cell adhesion molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
cell adhesion	TAS	9426258
homophilic cell adhesion via plasma membrane adhesion molecules	ISS
homophilic cell adhesion via plasma membrane adhesion molecules	IBA
negative regulation of cell adhesion	ISS
nervous system development	TAS	9426258

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

behavior [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

system development [inference]

dendritic spine development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	ISS
plasma membrane	TAS
plasma membrane	IBA
membrane	TAS	9426258

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19196994 32296183 35914814
cell-cell adhesion mediator activity	IBA
protein tyrosine kinase binding	IEA
netrin receptor binding	IPI	22685302

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

netrin receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Down syndrome cell adhesion molecule-like protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1826	Xenbase:XB-GENE-921689
Mus musculus	13508	Xenbase:XB-GENE-921689	MOUSE18568
Xenopus tropicalis	35652	Xenbase:XB-GENE-921689
Drosophila melanogaster	57453	FB:FBgn0033159
Drosophila melanogaster	114873	FB:FBgn0033159
Rattus norvegicus	171119	Xenbase:XB-GENE-921689	RATNO04091
Macaca mulatta	722556		MACMU30544
Pan troglodytes	747803		PANTR25709
Monodelphis domestica	100016941		MONDO21539
Equus caballus	100058783		HORSE24737

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements