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desmoglein 2

Summary

Gene Symbol

DSG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1829

PubChem

1829

Alliance of Genome Resources

HGNC:3049

Annotation

Keyword

3D-structure
Calcium
Cardiomyopathy
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Disease variant
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14126	Cadherin family member 5 HDGC

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
desmosome organization	IMP	16505173
response to progesterone	IEA
regulation of heart rate by cardiac conduction	IMP	16505173 23381804
homophilic cell adhesion via plasma membrane adhesion molecules	IDA	17559062

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

homotypic cell-cell adhesion [inference]

cardiac muscle cell-cardiac muscle cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

heterotypic cell-cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell-cell junction organization [inference]

desmosome organization

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development [inference]

ventricular cardiac muscle tissue development [inference]

Purkinje myocyte development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to progesterone

response to lipid [inference]

response to steroid hormone [inference]

response to progesterone

response to ketone [inference]

response to progesterone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to progesterone

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell junction	IDA
cornified envelope	TAS
desmosome	IBA IDA	20859650 23381804
lateral plasma membrane	IEA
apical plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cornified envelope

plasma membrane region [inference]

apical plasma membrane

lateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction

desmosome

cell-cell contact zone [inference]

intercalated disc

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11790773
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	IC	16505173
calcium ion binding	IBA
cell adhesion molecule binding	IPI	17559062

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

protein binding involved in heterotypic cell-cell adhesion [inference]

cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Desmoglein-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Catenin binding domain superfamily
Desmosomal cadherin

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0060036	intrinsic cardiomyopathy	Alliance of Genome Resources
DOID:0110081	arrhythmogenic right ventricular dysplasia 10	Alliance of Genome Resources
DOID:0110458	dilated cardiomyopathy 1BB	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13511		MGI:1196466	MOUSE23218
Rattus norvegicus	307562		RGD:1311143	RATNO14011
Pan troglodytes	455356	9598_0:004945		PANTR16084
Canis lupus familiaris	490500			CANLF17555
Bos taurus	508151			BOVIN19495
Danio rerio	560026		ZFIN:ZDB-GENE-030131-7531
Macaca mulatta	705805			MACMU17390
Monodelphis domestica	100031117			MONDO17682
Taeniopygia guttata	100232707			TAEGU18031
Oryctolagus cuniculus	100348149			RABIT13131

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements