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dual specificity phosphatase 3

Summary

Gene Symbol

DUSP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1845

PubChem

1845

Alliance of Genome Resources

HGNC:3069

JoGo

DUSP3

TogoVar

DUSP3

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Flagellum
Nucleus
Protein phosphatase
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P51452	Dual specificity protein phosphatase VHR Vaccinia H1-related phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 24** of 24 in total

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GO Term	Evidence Code	PMID
negative regulation of ERK1 and ERK2 cascade	IBA
cellular response to epidermal growth factor stimulus	IMP	28759036
positive regulation of focal adhesion disassembly	IMP	28759036
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISS	28759036

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to epidermal growth factor [inference]

cellular response to epidermal growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to epidermal growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to epidermal growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of immune response [inference]

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of chemotaxis [inference]

negative regulation of chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell-substrate junction organization [inference]

positive regulation of focal adhesion disassembly

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of locomotion [inference]

negative regulation of chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of immune response [inference]

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of T cell receptor signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell-substrate junction organization [inference]

positive regulation of focal adhesion disassembly

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of T cell receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell-substrate junction organization [inference]

positive regulation of focal adhesion disassembly

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of focal adhesion disassembly [inference]

positive regulation of focal adhesion disassembly

positive regulation of cell-substrate junction organization [inference]

positive regulation of focal adhesion disassembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
immunological synapse	IDA	12447358
nucleus	IDA	16604064
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	TAS
protein tyrosine phosphatase activity	IDA	11863439
protein tyrosine phosphatase activity	IMP	28759036
non-membrane spanning protein tyrosine phosphatase activity	IEA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity [inference]

calcium-dependent protein serine/threonine phosphatase activity [inference]

calmodulin-dependent protein phosphatase activity

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

protein tyrosine phosphatase activity

protein tyrosine/serine/threonine phosphatase activity

MAP kinase phosphatase activity

MAP kinase serine/threonine phosphatase activity

histone phosphatase activity [inference]

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity [inference]

calcium-dependent protein serine/threonine phosphatase activity [inference]

calmodulin-dependent protein phosphatase activity

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

protein tyrosine phosphatase activity

protein tyrosine/serine/threonine phosphatase activity

MAP kinase phosphatase activity

MAP kinase serine/threonine phosphatase activity

histone phosphatase activity [inference]

histone modifying activity [inference]

histone phosphatase activity [inference]

RNA polymerase II CTD heptapeptide repeat modifying activity [inference]

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

binding [inference]

protein binding

signaling receptor binding [inference]

receptor tyrosine kinase binding

cytoskeletal protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein tyrosine kinase binding

receptor tyrosine kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual specificity phosphatase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
MAP kinase phosphatase activity
dephosphorylation
hydrolase activity
negative regulation of ERK1 and ERK2 cascade
negative regulation of JNK cascade
negative regulation of T cell activation
negative regulation of T cell receptor signaling pathway
phosphoprotein phosphatase activity
positive regulation of mitotic cell cycle
protein tyrosine phosphatase activity

Displaying **all 6** entries
InterPro
Atypical dual specificity phosphatase, subfamily A
Dual specificity phosphatase, catalytic domain
Dual specificity protein phosphatase domain
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatases domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements