GlyCosmos Portal

Submissions

proprotein convertase subtilisin/kexin type 1

Summary

Gene Symbol

Pcsk1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18548

PubChem

18548

Alliance of Genome Resources

MGI:97511

Annotation

Keyword

3D-structure
Calcium
Cleavage on pair of basic residues
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q32MU0	Prohormone convertase 1 Proprotein convertase 1
P63239	Furin homolog PC3 Prohormone convertase 1 Propeptide-processing protease Proprotein convertase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
response to xenobiotic stimulus	IEA
response to glucose	IEA
response to chlorate	IEA
protein processing	ISO
protein processing	IDA	9242664

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

insulin processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

pancreas development

gland development [inference]

pituitary gland development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to fatty acid

response to cytokine [inference]

response to interleukin-1

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to chlorate

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to peptide [inference]

response to peptide hormone

response to salt [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

insulin processing

Displaying entries **1 - 5** of 21 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	8397508
extracellular space	IBA
endoplasmic reticulum lumen	TAS
trans-Golgi network	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IDA	9242664
serine-type endopeptidase activity	TAS
serine-type endopeptidase activity	IDA	8262946
serine-type endopeptidase activity	IMP	12136131

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:28	endocrine system disease	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **104** in total

« First

‹ Prev

1

2

3

4

5

6

7

8

…

Next ›

Last »
Species	Gene ID	Orthologous MAtrix
Danio rerio	100005716	DANRE21674
Monodelphis domestica	100010673	MONDO18627
Equus caballus	100064886	HORSE08329
Ornithorhynchus anatinus	100081484	ORNAN12708
Pongo abelii	100173253	PONAB30133
Taeniopygia guttata	100226064	TAEGU31460
Oryctolagus cuniculus	100345424	RABIT01807
Callithrix jacchus	100403507	CALJA26043
Ailuropoda melanoleuca	100484463	AILME05355
Nomascus leucogenys	100606392	NOMLE26228

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements