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proprotein convertase subtilisin/kexin type 6

Summary

Gene Symbol

Pcsk6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18553

PubChem

18553

Alliance of Genome Resources

MGI:102897

Annotation

Keyword

Cleavage on pair of basic residues
Proteomics identification
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9Q4D0
F6XJP7

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
zygotic determination of anterior/posterior axis, embryo	IMP	10809672
zygotic determination of anterior/posterior axis, embryo	IGI	10809672
determination of left/right symmetry	IGI	10809672
glycoprotein metabolic process	ISO
protein processing	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

export from cell [inference]

secretion by cell

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

anterior/posterior axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

embryonic pattern specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

neurotrophin production [inference]

nerve growth factor production

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell

export from cell [inference]

secretion by cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IBA
endoplasmic reticulum lumen
cell surface	ISO
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endopeptidase activity	ISO
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
heparin binding	ISO
nerve growth factor binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5045	SGD:S000005182
Homo sapiens	5046	Xenbase:XB-GENE-979058	HUMAN25292
Saccharomyces cerevisiae S288C	5122	SGD:S000005182
Saccharomyces cerevisiae S288C	5125	SGD:S000005182
Saccharomyces cerevisiae S288C	9159	SGD:S000005182
Saccharomyces cerevisiae S288C	18548	SGD:S000005182
Saccharomyces cerevisiae S288C	18550	SGD:S000005182
Saccharomyces cerevisiae S288C	18551	SGD:S000005182
Saccharomyces cerevisiae S288C	18552	SGD:S000005182
Xenopus tropicalis	18553	Xenbase:XB-GENE-979058

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Acknowledgements