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programmed cell death 1

Summary

Gene Symbol

Pdcd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18566

PubChem

18566

Alliance of Genome Resources

MGI:104879

Annotation

Keyword

3D-structure
Adaptive immunity
Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Isopeptide bond
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q02242
Q544F3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
negative regulation of T cell activation	ISO ISS
positive regulation of T cell apoptotic process	IBA IMP	23636058
negative regulation of immune response	IMP	10485649 11209085
negative regulation of tolerance induction	IMP	23636058
negative regulation of B cell apoptotic process	IMP	23636058

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

B cell apoptotic process

T cell apoptotic process [inference]

regulatory T cell apoptotic process

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

negative regulation of tolerance induction

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of developmental process [inference]

negative regulation of tolerance induction

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of tolerance induction

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of lymphocyte apoptotic process [inference]

regulation of B cell apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

regulation of T cell apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

Displaying 1 entry
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA IDA	15568026 23583643

GO Hierarchy

cellular component

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
signaling receptor activity	ISO ISS
protein binding	IPI	15568026 18641123 21884581 23417675

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

1

2

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DO ID	Disease Name	Source
DOID:0080159	Cryptococcal meningitis	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:11168	anogenital venereal wart	Alliance of Genome Resources
DOID:12549	hepatitis A	Alliance of Genome Resources
DOID:1273	respiratory syncytial virus infectious disease	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources

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