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MIRAGE
dual specificity tyrosine phosphorylation regulated kinase 1A
Summary
- Gene Symbol
-
- DYRK1A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Host-virus interaction
- Intellectual disability
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Serine/threonine-protein kinase
- Transcription regulation
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13627 |
|
| A0A2R8Y6I6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromatin remodeling | ||
| regulation of transcription by RNA polymerase II | ||
| protein phosphorylation | ||
| protein phosphorylation | ||
| nervous system development |
GO Hierarchy
biological process
metabolic process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transcription coactivator activity | ||
| actin binding | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- dual specificity
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| protein phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060041 | autism spectrum disorder | |
| DOID:0070037 | autosomal dominant intellectual developmental disorder 7 | |
| DOID:1059 | intellectual disability |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1859 | Xenbase:XB-GENE-1017105 | ||
| 13548 | MOUSE18241 | ||
| 13549 | FB:FBgn0259168 | ||
| 25255 | RATNO04730 | ||
| 32771 | Xenbase:XB-GENE-1017105 | ||
| 458545 | PANTR25671 | ||
| 487755 | CANLF12870 | ||
| 693812 | MACMU30630 | ||
| 853300 | ZFIN:ZDB-GENE-030131-5677 | ||
| 100019775 | MONDO21684 |
