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angiotensin II receptor type 1

Summary

Gene Symbol

AGTR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

185

PubChem

185

Alliance of Genome Resources

HGNC:336

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host-virus interaction
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
D3DNG8
P30556	AT1AR AT1BR Angiotensin II type-1 receptor
Q6NUP5
A0A0A0MSE3
Q53YY0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 28 in total

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GO Term	Evidence Code	PMID
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	25850724
viral entry into host cell	IDA	33713620
positive regulation of macrophage derived foam cell differentiation	IMP	18971559
phospholipase C-activating G protein-coupled receptor signaling pathway	IDA NAS	1567413 17159080
inflammatory response	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renin-angiotensin regulation of aldosterone production

renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [inference]

maintenance of blood vessel diameter homeostasis by renin-angiotensin

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process

regulation of signaling [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion [inference]

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response

positive regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cell population proliferation

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of cellular component organization [inference]

regulation of cell growth

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of renal system process [inference]

regulation of renal sodium excretion

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase A2 activity

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase A2 activity

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase A2 activity

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase A2 activity

regulation of phospholipase A2 activity [inference]

positive regulation of phospholipase A2 activity

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase A2 activity

regulation of transferase activity [inference]

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

regulation of CoA-transferase activity [inference]

positive regulation of CoA-transferase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	NAS	8135787
plasma membrane	IBA IC IDA TAS	1378723 19023134 33713620

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	1378723 15611106 19023134 21412239 22935142 23597562 26460884 28298427
angiotensin type I receptor activity	IBA IDA IPI	10993080 1378723 15611106 25913193 26420482 30639100 32079768 8987975
protein heterodimerization activity	IPI	10993080
bradykinin receptor binding	IPI	10993080
angiotensin type II receptor activity	IDA	1567413

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

type-1 angiotensin ii receptor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
angiotensin type I receptor activity
angiotensin type II receptor activity
angiotensin-activated signaling pathway
brain development
calcium-mediated signaling
cell chemotaxis
immune response
neurogenesis

Displaying **all 3** entries
InterPro
Angiotensin II receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **21 - 30** of 32 in total

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DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3407	carotid artery disease	Alliance of Genome Resources
DOID:3891	placental insufficiency	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:4780	anti-basement membrane glomerulonephritis	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:6713	cerebrovascular disease	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **115** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Meleagris gallopavo	100303701			MELGA02715
Danio rerio	100333455		ZFIN:ZDB-GENE-110411-117	DANRE25855
Callithrix jacchus	100406419			CALJA15578
Pongo abelii	100461588	9601_0:001128		PONAB26682
Ailuropoda melanoleuca	100471220			AILME04727
Sus scrofa	100519976			PIGXX04895
Anolis carolinensis	100555655			ANOCA04057
Nomascus leucogenys	100603931			NOMLE03850
Oreochromis niloticus	100702961			ORENI74787
Cricetulus griseus	100750798			CRIGR18640

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OrthoDB (Group)

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Acknowledgements