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NAD(P)H oxidase (H2O2-forming)

Summary

Gene Symbol

duox-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

186188

PubChem

186188

Alliance of Genome Resources

WB:WBGene00018771

Annotation

Keyword

Calcium
FAD
Glycoprotein
Heme
NADP
Oxidoreductase
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O01795

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
superoxide anion generation	IBA
cuticle development involved in collagen and cuticulin-based cuticle molting cycle	IMP	12619137
post-embryonic body morphogenesis	IMP	12619137
defense response	IBA
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic body morphogenesis

body morphogenesis [inference]

post-embryonic body morphogenesis

anatomical structure development [inference]

cuticle development [inference]

collagen and cuticulin-based cuticle development [inference]

cuticle development involved in collagen and cuticulin-based cuticle molting cycle

response to stimulus [inference]

response to stress [inference]

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
NADPH oxidase complex	IBA
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
superoxide-generating NAD(P)H oxidase activity	IBA
metal ion binding	IEA
peroxidase activity	IEA
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

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InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	Alliance of Genome Resources
DOID:0050338	primary bacterial infectious disease	Alliance of Genome Resources
DOID:0112189	thyroid dyshormonogenesis 6	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:1498	cholera	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 13 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Drosophila melanogaster	33477		FB:FBgn0283531
Homo sapiens	50506		HGNC:13273
Homo sapiens	53905		HGNC:3062
Rattus norvegicus	79107		RGD:628761
Mus musculus	99439		MGI:2139422
Mus musculus	214593		MGI:3036280
Rattus norvegicus	266807		RGD:628760
Danio rerio	565097		ZFIN:ZDB-GENE-091117-14
Brugia malayi	6104011	6279_0:000588
Loa loa	9941150	7209_0:002543

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements