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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
endothelin receptor type A
Summary
- Gene Symbol
-
- EDNRA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disease variant
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Hypotrichosis
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P25101 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| norepinephrine metabolic process | ||
| protein transmembrane transport | ||
| neuromuscular process | ||
| response to wounding | ||
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| endothelin receptor activity | ||
| protein binding | ||
| phosphatidylinositol phospholipase C activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| G protein-coupled peptide receptor activity |
| neuropeptide receptor activity |
| InterPro |
|---|
| Bombesin receptor-like |
| G protein-coupled receptor, rhodopsin-like |
| GPCR, rhodopsin-like, 7TM |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050855 | renal fibrosis | |
| DOID:0060365 | mandibulofacial dysostosis with alopecia | |
| DOID:10762 | portal hypertension | |
| DOID:10763 | hypertension | |
| DOID:1184 | nephrotic syndrome | |
| DOID:12583 | velocardiofacial syndrome | |
| DOID:1875 | impotence | |
| DOID:5844 | myocardial infarction | |
| DOID:6364 | migraine |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 13617 | MGI:105923 | MOUSE57608 | ||
| 24326 | RGD:2535 | RATNO14674 | ||
| 114550 | ZFIN:ZDB-GENE-010906-2 | DANRE17351 | ||
| 281749 | BOVIN09095 | |||
| 380342 | Xenbase:XB-GENE-1007000 | |||
| 397457 | PIGXX34040 | |||
| 405866 | ZFIN:ZDB-GENE-040426-2364 | |||
| 443465 | SHEEP07139 | |||
| 450187 | CANLF04313 | |||
| 461530 | 9598_0:0014e8 | PANTR34604 |
