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MIRAGE

Palmitoyl-protein thioesterase 1

Summary

Gene Symbol

ppt-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

191744

PubChem

191744

Alliance of Genome Resources

WB:WBGene00004092

Annotation

Keyword

Disulfide bond
Glycoprotein
Hydrolase
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q20390	Palmitoyl-protein hydrolase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
endocytosis	IBA
receptor-mediated endocytosis
mitochondrion organization	IMP	15672447
nervous system development	IBA
post-embryonic development	IMP	15672447

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

macromolecule modification [inference]

macromolecule deacylation [inference]

macromolecule depalmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

receptor-mediated endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

reproductive process [inference]

reproductive behavior [inference]

egg-laying behavior

multicellular organismal process [inference]

behavior [inference]

reproductive behavior [inference]

egg-laying behavior

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

receptor-mediated endocytosis

import into cell [inference]

receptor-mediated endocytosis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
lysosome	ISS	15672447
lysosome	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
palmitoyl-(protein) hydrolase activity	IDA	15672447
palmitoyl-(protein) hydrolase activity	IBA
palmitoyl-(protein) hydrolase activity	IEA
hydrolase activity	IEA
long-chain acyl-CoA hydrolase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

CoA hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

long-chain acyl-CoA hydrolase activity

palmitoyl hydrolase activity

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

palmitoyl-protein thioesterase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
macromolecule depalmitoylation
nervous system development
palmitoyl hydrolase activity
palmitoyl-(protein) hydrolase activity
receptor-mediated endocytosis

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Palmitoyl protein thioesterase

Rhea

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.22

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14503	neuronal ceroid lipofuscinosis	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5538	Xenbase:XB-GENE-923070
Xenopus tropicalis	19063	Xenbase:XB-GENE-923070
Xenopus tropicalis	29411	Xenbase:XB-GENE-923070
Xenopus tropicalis	31805	Xenbase:XB-GENE-923070
Xenopus tropicalis	191744	Xenbase:XB-GENE-923070

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.0

Last updated: March 31, 2025