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nectin cell adhesion molecule 1

Summary

Gene Symbol

Nectin1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192183

PubChem

192183

Alliance of Genome Resources

RGD:620791

Annotation

Keyword

Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F1LNP8
A6J3U6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
axon guidance	IMP	15328010
viral entry into host cell	IMP	12584355
lens morphogenesis in camera-type eye	ISO
positive regulation of viral entry into host cell	ISO
enamel mineralization	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell-cell junction organization [inference]

desmosome organization

developmental process [inference]

anatomical structure morphogenesis [inference]

lens morphogenesis in camera-type eye

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

camera-type eye morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

retina development in camera-type eye

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell-cell contact zone	ISO
growth cone membrane	IDA	18181141
apical junction complex	ISO
hippocampal mossy fiber to CA3 synapse	ISO
adherens junction	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

anchoring junction [inference]

cell-cell junction [inference]

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
cell adhesion molecule binding	ISO
protein homodimerization activity	ISO
carbohydrate binding	IDA	18181141

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

nectin-1

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
identical protein binding
protein localization to cell junction

Displaying **all 9** entries
InterPro
CD80-like, immunoglobulin C2-set
Immunoglobulin V-set domain
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Nectin-1, first immunoglobulin variable domain
Nectin-1, second immunoglobulin domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
growth cone membrane	PMID:18181141
dendrite	PMID:16801389
axon	PMID:16801389

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060773	cleft lip-palate-ectodermal dysplasia syndrome	Alliance of Genome Resources
DOID:2121	ectodermal dysplasia	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of **121** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Castor canadensis	109676720	51338_0:004d54
Castor canadensis	109676722	51338_0:004d56
Phascolarctos cinereus	110207230		PHACI23064
Mus caroli	110301794	10089_0:002a88
Mus pahari	110327633	10093_0:002b89
Meriones unguiculatus	110548549	10047_0:00130a
Seriola dumerili	111233637		SERDU28620
Amphiprion ocellaris	111575396		AMPOC10261
Vulpes vulpes	112920316		VULVU12782
Astatotilapia calliptera	113036507		ASTCA08573

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements