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nectin cell adhesion molecule 1

Summary

Gene Symbol

Nectin1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192183

PubChem

192183

Alliance of Genome Resources

RGD:620791

Annotation

Keyword

Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F1LNP8
A6J3U6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of synapse organization	EXP IDA	11827984
cell-cell adhesion	ISO
iron ion transport	ISO
desmosome organization	ISO
protein localization to cell junction	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell-cell junction organization [inference]

desmosome organization

developmental process [inference]

anatomical structure morphogenesis [inference]

lens morphogenesis in camera-type eye

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

camera-type eye morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

retina development in camera-type eye

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
dendrite	IDA	16801389
axon	IDA	16801389
presynaptic active zone membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

anchoring junction [inference]

cell-cell junction [inference]

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
cell adhesion molecule binding	ISO
protein homodimerization activity	ISO
carbohydrate binding	IDA	18181141

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

nectin-1

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
identical protein binding
protein localization to cell junction

Displaying **all 9** entries
InterPro
CD80-like, immunoglobulin C2-set
Immunoglobulin V-set domain
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Nectin-1, first immunoglobulin variable domain
Nectin-1, second immunoglobulin domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
growth cone membrane	PMID:18181141
dendrite	PMID:16801389
axon	PMID:16801389

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060773	cleft lip-palate-ectodermal dysplasia syndrome	Alliance of Genome Resources
DOID:2121	ectodermal dysplasia	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **121** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cricetulus griseus	100759778	10029_0:002cfa
Sarcophilus harrisii	100914634		SARHA02074
Otolemur garnettii	100953486		OTOGA06073
Pan paniscus	100985009		PANPA08155
Papio anubis	101010547		PAPAN05441
Saimiri boliviensis boliviensis	101042748		SAIBB06380
Takifugu rubripes	101065982		TAKRU05013
Felis catus	101098252		FELCA24334
Oryzias latipes	101170036		ORYLA03129
Octodon degus	101569486	10160_0:00294e	OCTDE14630

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements