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nectin cell adhesion molecule 1

Summary

Gene Symbol

Nectin1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192183

PubChem

192183

Alliance of Genome Resources

RGD:620791

Annotation

Keyword

Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F1LNP8
A6J3U6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of synapse organization	EXP IDA	11827984
cell-cell adhesion	ISO
iron ion transport	ISO
desmosome organization	ISO
protein localization to cell junction	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell-cell junction organization [inference]

desmosome organization

developmental process [inference]

anatomical structure morphogenesis [inference]

lens morphogenesis in camera-type eye

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

camera-type eye morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

retina development in camera-type eye

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
dendrite	IDA	16801389
axon	IDA	16801389
presynaptic active zone membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

anchoring junction [inference]

cell-cell junction [inference]

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
cell adhesion molecule binding	ISO
protein homodimerization activity	ISO
carbohydrate binding	IDA	18181141

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

nectin-1

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
identical protein binding
protein localization to cell junction

Displaying **all 9** entries
InterPro
CD80-like, immunoglobulin C2-set
Immunoglobulin V-set domain
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Nectin-1, first immunoglobulin variable domain
Nectin-1, second immunoglobulin domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
growth cone membrane	PMID:18181141
dendrite	PMID:16801389
axon	PMID:16801389

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060773	cleft lip-palate-ectodermal dysplasia syndrome	Alliance of Genome Resources
DOID:2121	ectodermal dysplasia	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **121** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Serinus canaria	103823044		SERCA19928
Rhinopithecus roxellana	104657223		RHIRO17103
Fukomys damarensis	104865648	885580_0:001d83
Esox lucius	105012979		ESOLU02286
Macaca nemestrina	105476359		MACNE14742
Mandrillus leucophaeus	105528256		MANLE06770
Cercocebus atys	105582520		CERAT14974
Aotus nancymaae	105729503		AOTNA05844
Propithecus coquereli	105810871		PROCO20423
Dipodomys ordii	105980623	10020_0:000ace	DIPOR03105

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements