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protein tyrosine phosphatase, non-receptor type 13

Summary

Gene Symbol

Ptpn13

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19249

PubChem

19249

Alliance of Genome Resources

MGI:103293

Annotation

Keyword

3D-structure
Cell projection
Coiled coil
Cytoskeleton
Nucleus
Phosphoprotein
Protein phosphatase
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 5** entries
UniProt	Protein Name
G5E8B1
Q3TTT8
Q3TPD6
Q8BV52
Q64512	PTP36 Protein tyrosine phosphatase DPZPTP Protein tyrosine phosphatase PTP-BL Protein-tyrosine phosphatase RIP

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of protein phosphorylation	ISO
peptidyl-tyrosine dephosphorylation	ISO
negative regulation of excitatory synapse assembly	IBA ISO
protein dephosphorylation	IEA ISO
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of developmental process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of excitatory synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of excitatory synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of excitatory synapse assembly [inference]

negative regulation of excitatory synapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of excitatory synapse assembly

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
midbody	IDA	23108400
plasma membrane	ISO
nucleoplasm	ISO
cell body	ISO
lamellipodium	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

midbody

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

cell body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10526152 10826496 12839623 15663004
protein tyrosine phosphatase activity	IBA ISO ISS
phosphatidylinositol 3-kinase regulatory subunit binding	IBA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

protein binding

phosphatidylinositol 3-kinase binding [inference]

phosphatidylinositol 3-kinase regulatory subunit binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Tyrosine-protein phosphatase non-receptor type 13

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
dephosphorylation
phosphatidylinositol 3-kinase regulatory subunit binding
protein tyrosine phosphatase activity

Displaying **all 4** entries
InterPro
FERM central domain
FERM, C-terminal PH-like domain
FERM, N-terminal
PDZ domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources
DOID:3907	lung squamous cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4556	lung large cell carcinoma	Alliance of Genome Resources
DOID:5520	head and neck squamous cell carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Felis catus	100144609			FELCA09077
Xenopus tropicalis	100144727		Xenbase:XB-GENE-939886
Taeniopygia guttata	100223569			TAEGU24585
Callithrix jacchus	100389019			CALJA29427
Pongo abelii	100455138			PONAB27351
Ailuropoda melanoleuca	100477379			AILME18483
Anolis carolinensis	100566747			ANOCA07138
Nomascus leucogenys	100603082			NOMLE37314
Cavia porcellus	100717744	10141_0:00239b		CAVPO14410
Cricetulus griseus	100758903	10029_0:000c61

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements