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RAS protein-specific guanine nucleotide-releasing factor 2

Summary

Gene Symbol

Rasgrf2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19418

PubChem

19418

Alliance of Genome Resources

MGI:109137

Annotation

Keyword

Calcium
Calmodulin-binding
Cell membrane
Coiled coil
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
Guanine-nucleotide releasing factor
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P70392	Ras guanine nucleotide exchange factor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
small GTPase mediated signal transduction	IEA
Ras protein signal transduction	IBA
response to endoplasmic reticulum stress	ISO
response to endoplasmic reticulum stress	IEA
long-term synaptic potentiation	IGI	20661302

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Ras protein signal transduction

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

postsynaptic modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

postsynaptic modulation of chemical synaptic transmission

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of NMDA receptor activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA
plasma membrane	IBA
plasma membrane	IEA
postsynapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA
guanyl-nucleotide exchange factor activity	IEA
calmodulin binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

calmodulin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ras-specific guanine nucleotide-releasing factor

Functional Category

F: Nucleotide transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Ras protein signal transduction
small GTPase-mediated signal transduction

Displaying **all 5** entries
InterPro
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5900	SGD:S000000634
Saccharomyces cerevisiae S288C	5923	SGD:S000000634
Homo sapiens	5924	Xenbase:XB-GENE-483993	HUMAN79877
Saccharomyces cerevisiae S288C	10235	SGD:S000000634
Saccharomyces cerevisiae S288C	19417	SGD:S000000634
Xenopus tropicalis	19418	Xenbase:XB-GENE-483993
Rattus norvegicus	114513		RATNO24681
Saccharomyces cerevisiae S288C	115727	SGD:S000000634
Pan troglodytes	461771		PANTR35191
Bos taurus	524957		BOVIN33908