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ephrin B2

Summary

Gene Symbol

EFNB2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1948

PubChem

1948

Alliance of Genome Resources

HGNC:3227

Annotation

Keyword

3D-structure
Angiogenesis
Cell junction
Cell membrane
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Methylation
Neurogenesis
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P52799	EPH-related receptor tyrosine kinase ligand 5 HTK ligand

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IMP	26268439
lymph vessel development	IEA
venous blood vessel morphogenesis	IEA
regulation of postsynaptic membrane neurotransmitter receptor levels	IEA
adherens junction organization	IEA

GO Hierarchy

biological process

immune system process [inference]

lymphocyte costimulation [inference]

T cell costimulation

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration [inference]

cell migration involved in sprouting angiogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell-cell junction organization [inference]

adherens junction organization

developmental process [inference]

anatomical structure morphogenesis

animal organ morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

venous blood vessel morphogenesis

epithelial tube morphogenesis [inference]

nephric duct morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

nephric duct morphogenesis

anatomical structure development [inference]

lymph vessel development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

regulation of locomotion [inference]

regulation of chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of artery morphogenesis [inference]

regulation of aorta morphogenesis [inference]

positive regulation of aorta morphogenesis

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of artery morphogenesis [inference]

positive regulation of aorta morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cardiocyte differentiation [inference]

positive regulation of cardiac muscle cell differentiation

regulation of biological quality [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Schaffer collateral - CA1 synapse	IEA
postsynaptic density membrane	IEA
focal adhesion	HDA	21423176
plasma membrane	IBA IDA TAS	17251577 28931592
adherens junction	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12606549 15764601 18488039 19836338 26481148 28514442 28904190 32296183 33961781 35384245
ephrin receptor binding	IBA IPI	16867992
virus receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

ephrin receptor binding

exogenous protein binding [inference]

virus receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ephrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ephrin receptor binding
ephrin receptor signaling pathway

Displaying **all 4** entries
InterPro
Cupredoxin
Ephrin receptor-binding domain
Ephrin, conserved site
Ephrin

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:799	varicose veins	Alliance of Genome Resources
DOID:9261	nasopharynx carcinoma	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13642		MGI:105097	MOUSE59619
Danio rerio	30219		ZFIN:ZDB-GENE-990415-67	DANRE44788
Drosophila melanogaster	43799		FB:FBgn0040324
Danio rerio	114402		ZFIN:ZDB-GENE-010618-1
Caenorhabditis elegans	177949		WB:WBGene00001163
Rattus norvegicus	306636		RGD:1309497	RATNO11446
Xenopus laevis	379645		Xenbase:XB-GENE-6255186
Macaca mulatta	711288			MACMU16537
Pan troglodytes	735430	9598_0:0038b0		PANTR08057
Monodelphis domestica	100018256			MONDO32053

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements