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cadherin EGF LAG seven-pass G-type receptor 3

Summary

Gene Symbol

CELSR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1951

PubChem

1951

Alliance of Genome Resources

HGNC:3230

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ7	Cadherin family member 11 Epidermal growth factor-like protein 1 Flamingo homolog 1 Multiple epidermal growth factor-like domains protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
serotonergic neuron axon guidance	ISS
dopaminergic neuron axon guidance	ISS
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
Wnt signaling pathway, planar cell polarity pathway	NAS	24431302

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	15203201
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17474147
calcium ion binding	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin EGF LAG seven-pass G-type receptor 3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36125		FB:FBgn0024836
Rattus norvegicus	83466		RGD:621787	RATNO40976
Mus musculus	107934		MGI:1858236	MOUSE64418
Caenorhabditis elegans	179788		WB:WBGene00001475
Pan troglodytes	460350	9598_0:000ff3		PANTR31074
Canis lupus familiaris	476635			CANLF07530
Bos taurus	523793			BOVIN17871
Macaca mulatta	709315			MACMU29363
Danio rerio	100008568		ZFIN:ZDB-GENE-070122-3
Monodelphis domestica	100027138			MONDO28911