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cadherin EGF LAG seven-pass G-type receptor 3

Summary

Gene Symbol

CELSR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1951

PubChem

1951

Alliance of Genome Resources

HGNC:3230

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ7	Cadherin family member 11 Epidermal growth factor-like protein 1 Flamingo homolog 1 Multiple epidermal growth factor-like domains protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
G protein-coupled receptor signaling pathway	IEA
dopaminergic neuron axon guidance	ISS
serotonergic neuron axon guidance	ISS
Wnt signaling pathway, planar cell polarity pathway	NAS	24431302

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
membrane	TAS	15203201

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
calcium ion binding	IEA
protein binding	IPI	17474147

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin egf lag seven-pass g-type

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1951	Xenbase:XB-GENE-852799
Drosophila melanogaster	1952	FB:FBgn0024836
Drosophila melanogaster	9620	FB:FBgn0024836
Drosophila melanogaster	12614	FB:FBgn0024836
Xenopus tropicalis	36125	Xenbase:XB-GENE-852799
Drosophila melanogaster	53883	FB:FBgn0024836
Rattus norvegicus	83466	Xenbase:XB-GENE-852799	RATNO40976
Mus musculus	107934	Xenbase:XB-GENE-852799	MOUSE64418
Xenopus tropicalis	179788	Xenbase:XB-GENE-852799
Pan troglodytes	460350		PANTR31074