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eukaryotic translation initiation factor 2 subunit alpha

Summary

Gene Symbol

EIF2S1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1965

PubChem

1965

Alliance of Genome Resources

HGNC:3265

JoGo

EIF2S1

TogoVar

EIF2S1

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Initiation factor
Mitochondrion
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53XC0	Eukaryotic translation initiation factor 2 subunit alpha
P05198	Eukaryotic translation initiation factor 2 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitophagy	IDA	38340717
translational initiation	IDA	16289705
translational initiation	IBA
negative regulation of translational initiation in response to stress	ISS
stress granule assembly	ISS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular metabolic process [inference]

translational initiation

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

cellular metabolic process [inference]

translational initiation

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion [inference]

mitophagy

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to kainic acid

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to kainic acid

response to organic cyclic compound [inference]

response to kainic acid

response to inorganic substance [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to kainic acid

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to kainic acid

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of type B pancreatic cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
mitochondrion	IDA	38340717
cytosol	TAS
cytosol	IDA
eukaryotic translation initiation factor 2 complex	IDA	23063529

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

ribonucleoprotein complex [inference]

translation initiation ternary complex

translation preinitiation complex [inference]

eukaryotic 48S preinitiation complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
translation initiation factor activity	IDA	16289705
translation initiation factor activity	IBA
protein binding	IPI	11500362 16288713 16932749 17894550 18596238 18971339 22323517 25393282 26095357 28514442 32296183 33961781 35271311 37507029 9431994
ribosome binding	IDA	17894550

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translation initiation factor 2

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
IF2a, S1-like domain
Nucleic acid-binding, OB-fold
S1 domain
Translation initiation factor 2, alpha subunit, C-terminal
Translation initiation factor 2, alpha subunit, middle domain superfamily
Translation initiation factor 2, alpha subunit

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements