GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IWV7	N-recognin-1 Ubiquitin-protein ligase E3-alpha-1 Ubiquitin-protein ligase E3-alpha-I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	15548684
ubiquitin-dependent protein catabolic process via the N-end rule pathway	IBA IDA	16311597 18162545 20835242 28392261
negative regulation of TOR signaling	IMP	20298436
cellular response to leucine	IDA	20298436
protein ubiquitination	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteasome complex	IEA
ubiquitin ligase complex	IBA
cytosol	IDA	16311597
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16169070 21422291 28514442 32814053 33961781
zinc ion binding	IEA
ubiquitin protein ligase activity	IBA IDA	15548684 18162545
leucine binding	IDA	20298436

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

leucine binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

leucine binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 UBIQUITIN-PROTEIN LIGASE

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
metal ion binding
protein ubiquitination
transferase activity
ubiquitin-dependent protein catabolic process via the N-end rule pathway
zinc ion binding

Displaying **all 5** entries
InterPro
E3 ubiquitin-protein ligase ELL-like
E3 ubiquitin-protein ligase UBR-like, C-terminal
E3 ubiquitin-protein ligase UBR1-like
Winged helix DNA-binding domain superfamily
Zinc finger, UBR-type

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:14694	Johanson-Blizzard syndrome	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22222		MGI:1277977	MOUSE32235
Drosophila melanogaster	32687		FB:FBgn0030809
Caenorhabditis elegans	171953		WB:WBGene00016326
Pan troglodytes	453369	9598_0:003e0e		PANTR10113
Canis lupus familiaris	487521			CANLF12442
Rattus norvegicus	499877		RGD:1562326	RATNO27052
Bos taurus	522464			BOVIN01101
Danio rerio	568531		ZFIN:ZDB-GENE-091110-2
Macaca mulatta	709238			MACMU41893
Saccharomyces cerevisiae S288C	853096		SGD:S000003416

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements