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MIRAGE

DAN domain BMP antagonist family member 5

Summary

Gene Symbol

DAND5

Organism

Homo sapiens (human)

External Links

NCBI Gene

199699

PubChem

199699

Alliance of Genome Resources

HGNC:26780

JoGo

DAND5

TogoVar

DAND5

Annotation

Keyword

Disulfide bond
Glycoprotein
Heterotaxy
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N907	Cerberus-like protein 2 Cysteine knot superfamily 1, BMP antagonist 3 Gremlin-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
determination of left/right asymmetry in lateral mesoderm	ISS
determination of left/right asymmetry in lateral mesoderm	NAS	17507406
ventricular septum development	ISS
atrial septum development	ISS
determination of left/right symmetry	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway [inference]

nodal signaling pathway

signal transduction involved in regulation of gene expression

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure development [inference]

cardiac septum development [inference]

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

sequestering of BMP in extracellular matrix

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway [inference]

nodal signaling pathway

signal transduction involved in regulation of gene expression

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	15466485
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
morphogen activity	ISS
morphogen activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

morphogen activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

morphogen activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

morphogen activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DAN domain family member 5

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
determination of heart left/right asymmetry
negative regulation of activin receptor signaling pathway
regionalization

Displaying **all 4** entries
InterPro
Cerberus
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

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Last updated: April 6, 2026